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Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses.
Reid KT, Colpitts SJ, Mathews JA, Santos Carreira A, Murphy JM, Borovsky DT, Jegatheeswaran S, Cui W, Alfaro Moya T, Sachewsky N, An J, Xia Y, Mortha A, Lee JB, Zhang L, Novitzky-Basso I, Mattsson J, Crome SQ. Reid KT, et al. Among authors: mortha a. Cell Rep. 2024 Dec 24;44(1):115102. doi: 10.1016/j.celrep.2024.115102. Online ahead of print. Cell Rep. 2024. PMID: 39721022 Free article.
A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity.
Burrows K, Ngai L, Chiaranunt P, Watt J, Popple S, Forde B, Denha S, Olyntho VM, Tai SL, Cao EY, Tejeda-Garibay S, Koenig JFE, Mayer-Barber KD, Streutker CJ, Hoyer KK, Osborne LC, Liu J, O'Mahony L, Mortha A. Burrows K, et al. Among authors: mortha a. Cell. 2024 Dec 12:S0092-8674(24)01336-9. doi: 10.1016/j.cell.2024.11.020. Online ahead of print. Cell. 2024. PMID: 39706191
The protozoan commensal Tritrichomonas musculis is a natural adjuvant for mucosal IgA.
Cao EY, Burrows K, Chiaranunt P, Popovic A, Zhou X, Xie C, Thakur A, Britton G, Spindler M, Ngai L, Tai SL, Dasoveanu DC, Nguyen A, Faith JJ, Parkinson J, Gommerman JL, Mortha A. Cao EY, et al. Among authors: mortha a. J Exp Med. 2024 Dec 2;221(12):e20221727. doi: 10.1084/jem.20221727. Epub 2024 Nov 13. J Exp Med. 2024. PMID: 39535524 Free PMC article.
Amplification of autoimmune organ damage by NKp46-activated ILC1s.
Biniaris-Georgallis SI, Aschman T, Stergioula K, Schreiber F, Jafari V, Taranko A, Karmalkar T, Kasapi A, Lenac Rovis T, Jelencic V, Bejarano DA, Fabry L, Papacharalampous M, Mattiola I, Molgora M, Hou J, Hublitz KW, Heinrich F, Guerra GM, Durek P, Patone G, Lindberg EL, Maatz H, Hölsken O, Krönke G, Mortha A, Voll RE, Clarke AJ, Hauser AE, Colonna M, Thurley K, Schlitzer A, Schneider C, Stamatiades EG, Mashreghi MF, Jonjic S, Hübner N, Diefenbach A, Kanda M, Triantafyllopoulou A. Biniaris-Georgallis SI, et al. Among authors: mortha a. Nature. 2024 Oct;634(8035):952-960. doi: 10.1038/s41586-024-07907-x. Epub 2024 Aug 13. Nature. 2024. PMID: 39137897
Actin branching maintains tissue-resident mast cells.
Ngai L, Mortha A. Ngai L, et al. Among authors: mortha a. Nat Rev Immunol. 2024 Aug;24(8):541. doi: 10.1038/s41577-024-01060-2. Nat Rev Immunol. 2024. PMID: 38956311 No abstract available.
Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer's disease in mice.
Makhijani P, Emani R, Aguirre CG, Mu WC, Rane A, Ng JHY, Valentino TR, Manwaring-Mueller M, Tan CR, Du H, Wu F, Khan S, Wilson KA, Winer S, Wang C, Mortha A, Furman D, Ellerby LM, Rojas OL, Andersen JK, Winer DA. Makhijani P, et al. Among authors: mortha a. bioRxiv [Preprint]. 2024 Jan 30:2024.01.27.573841. doi: 10.1101/2024.01.27.573841. bioRxiv. 2024. PMID: 38352325 Free PMC article. Preprint.
60 results