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An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.
Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, Roth BL, Brown PJ, Frye SV, Arrowsmith CH, Hahn KM, Wang GG, Vedadi M, Jin J. Konze KD, et al. Among authors: frye sv. ACS Chem Biol. 2013;8(6):1324-34. doi: 10.1021/cb400133j. Epub 2013 Apr 24. ACS Chem Biol. 2013. PMID: 23614352 Free PMC article.
Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.
Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, James LI, Frye SV. Perfetti MT, et al. Among authors: frye sv. ACS Chem Biol. 2015 Apr 17;10(4):1072-81. doi: 10.1021/cb500956g. Epub 2015 Jan 28. ACS Chem Biol. 2015. PMID: 25590533 Free PMC article.
Chemical probes for methyl lysine reader domains.
James LI, Frye SV. James LI, et al. Among authors: frye sv. Curr Opin Chem Biol. 2016 Aug;33:135-41. doi: 10.1016/j.cbpa.2016.06.004. Epub 2016 Jun 25. Curr Opin Chem Biol. 2016. PMID: 27348158 Free PMC article. Review.
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library.
Shell DJ, Rectenwald JM, Buttery PH, Johnson RL, Foley CA, Guduru SKR, Uguen M, Rubiano JS, Zhang X, Li F, Norris-Drouin JL, Axtman M, Brian Hardy P, Vedadi M, Frye SV, James LI, Pearce KH. Shell DJ, et al. Among authors: frye sv. SLAS Discov. 2022 Dec;27(8):428-439. doi: 10.1016/j.slasd.2022.10.003. Epub 2022 Oct 19. SLAS Discov. 2022. PMID: 36272689 Free article.
SETDB1 Triple Tudor Domain Ligand, (R,R)-59, Promotes Methylation of Akt1 in Cells.
Uguen M, Deng Y, Li F, Shell DJ, Norris-Drouin JL, Stashko MA, Ackloo S, Arrowsmith CH, James LI, Liu P, Pearce KH, Frye SV. Uguen M, et al. Among authors: frye sv. ACS Chem Biol. 2023 Aug 18;18(8):1846-1853. doi: 10.1021/acschembio.3c00280. Epub 2023 Aug 9. ACS Chem Biol. 2023. PMID: 37556795 Free PMC article.
142 results