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APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia.
Preman P, Moechars D, Fertan E, Wolfs L, Serneels L, Shah D, Lamote J, Poovathingal S, Snellinx A, Mancuso R, Balusu S, Klenerman D, Arranz AM, Fiers M, De Strooper B. Preman P, et al. Among authors: klenerman d. EMBO Mol Med. 2024 Dec;16(12):3113-3141. doi: 10.1038/s44321-024-00162-7. Epub 2024 Nov 11. EMBO Mol Med. 2024. PMID: 39528861 Free PMC article.
ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases.
Lobanova E, Zhang YP, Emin D, Brelstaff J, Kahanawita L, Malpetti M, Quaegebeur A, Triantafilou K, Triantafilou M, Zetterberg H, Rowe JB, Williams-Gray CH, Bryant CE, Klenerman D. Lobanova E, et al. Among authors: klenerman d. Nat Commun. 2024 Nov 11;15(1):9690. doi: 10.1038/s41467-024-53547-0. Nat Commun. 2024. PMID: 39528447 Free PMC article.
POLCAM: instant molecular orientation microscopy for the life sciences.
Bruggeman E, Zhang O, Needham LM, Körbel M, Daly S, Cheetham M, Peters R, Wu T, Klymchenko AS, Davis SJ, Paluch EK, Klenerman D, Lew MD, O'Holleran K, Lee SF. Bruggeman E, et al. Among authors: klenerman d. Nat Methods. 2024 Oct;21(10):1873-1883. doi: 10.1038/s41592-024-02382-8. Epub 2024 Oct 7. Nat Methods. 2024. PMID: 39375574 Free PMC article.
Aggregate-selective removal of pathological tau by clustering-activated degraders.
Benn J, Cheng S, Keeling S, Smith AE, Vaysburd MJ, Böken D, Miller LVC, Katsinelos T, Franco C, Dupré E, Danis C, Landrieu I, Buée L, Klenerman D, James LC, McEwan WA. Benn J, et al. Among authors: klenerman d. Science. 2024 Aug 30;385(6712):1009-1016. doi: 10.1126/science.adp5186. Epub 2024 Aug 29. Science. 2024. PMID: 39208111 Free PMC article.
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
Rajani RM, Ellingford R, Hellmuth M, Harris SS, Taso OS, Graykowski D, Lam FKW, Arber C, Fertan E, Danial JSH, Swire M, Lloyd M, Giovannucci TA, Bourdenx M, Klenerman D, Vassar R, Wray S, Sala Frigerio C, Busche MA. Rajani RM, et al. Among authors: klenerman d. PLoS Biol. 2024 Jul 23;22(7):e3002727. doi: 10.1371/journal.pbio.3002727. eCollection 2024 Jul. PLoS Biol. 2024. PMID: 39042667 Free PMC article.
Improved Imaging Surface for Quantitative Single-Molecule Microscopy.
Zhang YP, Lobanova E, Dworkin A, Furlepa M, Yang WS, Burke M, Meng JX, Potter N, Sala RL, Kahanawita L, Layburn F, Scherman OA, Williams-Gray CH, Klenerman D. Zhang YP, et al. Among authors: klenerman d. ACS Appl Mater Interfaces. 2024 Jul 17;16(28):37255-37264. doi: 10.1021/acsami.4c06512. Epub 2024 Jul 9. ACS Appl Mater Interfaces. 2024. PMID: 38979642 Free PMC article.
271 results