Gates KS - Search Results

1

Repurposing the Antihypertensive Agent Hydralazine As an Inhibitor of the Base Excision Repair Enzyme APE1.

Islam T, Nunna V, Liyanarachchi DP, Melton D, Lewis CD, Gates KS. Islam T, et al. Among authors: gates ks. Chem Res Toxicol. 2024 Dec 24. doi: 10.1021/acs.chemrestox.4c00445. Online ahead of print. Chem Res Toxicol. 2024. PMID: 39718352

2

Covalent adduct formation between the antihypertensive drug hydralazine and abasic sites in double- and single-stranded DNA.

Melton D, Lewis CD, Price NE, Gates KS. Melton D, et al. Among authors: gates ks. Chem Res Toxicol. 2014 Dec 15;27(12):2113-8. doi: 10.1021/tx5003657. Epub 2014 Nov 18. Chem Res Toxicol. 2014. PMID: 25405892 Free PMC article.

3

Ultrafast Reaction of the Drug Hydralazine with Apurinic/Apyrimidinic Sites in DNA Gives Rise to a Stable Triazolo[3,4-a]phthalazine Adduct.

Islam T, Shim G, Melton D, Lewis CD, Lei Z, Gates KS. Islam T, et al. Among authors: gates ks. Chem Res Toxicol. 2024 Jun 17;37(6):1023-1034. doi: 10.1021/acs.chemrestox.4c00098. Epub 2024 May 14. Chem Res Toxicol. 2024. PMID: 38743824

4

The Intercalator Ethidium Bromide Generates Covalent Adducts at Apurinic/Apyrimidinic Sites in DNA.

Islam T, Amin SBM, Gates KS. Islam T, et al. Among authors: gates ks. Chem Res Toxicol. 2024 Nov 18;37(11):1911-1917. doi: 10.1021/acs.chemrestox.4c00378. Epub 2024 Nov 3. Chem Res Toxicol. 2024. PMID: 39492465

5

Effects of Local Sequence, Reaction Conditions, and Various Additives on the Formation and Stability of Interstrand Cross-Links Derived from the Reaction of an Abasic Site with an Adenine Residue in Duplex DNA.

Amin SBM, Islam T, Price NE, Wallace A, Guo X, Gomina A, Heidari M, Johnson KM, Lewis CD, Yang Z, Gates KS. Amin SBM, et al. Among authors: gates ks. ACS Omega. 2022 Oct 4;7(41):36888-36901. doi: 10.1021/acsomega.2c05736. eCollection 2022 Oct 18. ACS Omega. 2022. PMID: 36278095 Free PMC article.

6

Formation and Properties of DNA Adducts Generated by Reactions of Abasic Sites with 1,2-Aminothiols Including Cysteamine, Cysteine Methyl Ester, and Peptides Containing N-Terminal Cysteine Residues.

Gomina A, Islam T, Shim G, Lei Z, Gates KS. Gomina A, et al. Among authors: gates ks. Chem Res Toxicol. 2024 Feb 19;37(2):395-406. doi: 10.1021/acs.chemrestox.3c00344. Epub 2024 Jan 5. Chem Res Toxicol. 2024. PMID: 38181204

7

Interstrand DNA Cross-Links Derived from Reaction of a 2-Aminopurine Residue with an Abasic Site.

Nejad MI, Price NE, Haldar T, Lewis C, Wang Y, Gates KS. Nejad MI, et al. Among authors: gates ks. ACS Chem Biol. 2019 Jul 19;14(7):1481-1489. doi: 10.1021/acschembio.9b00208. Epub 2019 Jul 1. ACS Chem Biol. 2019. PMID: 31259519 Free PMC article.

8

Allylation and Alkylation of Biologically Relevant Nucleophiles by Diallyl Sulfides.

Viswanatharaju Ruddraraju K, Parsons ZD, Lewis CD, Gates KS. Viswanatharaju Ruddraraju K, et al. Among authors: gates ks. J Org Chem. 2017 Jan 6;82(1):776-780. doi: 10.1021/acs.joc.6b02517. Epub 2016 Dec 14. J Org Chem. 2017. PMID: 27973787

9

Novel Processes Associated with the Repair of Interstrand Cross-Links Derived from Abasic Sites in Duplex DNA: Roles for the Base Excision Repair Glycosylase NEIL3 and the SRAP Protein HMCES.

Price NE, Gates KS. Price NE, et al. Among authors: gates ks. Chem Res Toxicol. 2024 Feb 19;37(2):199-207. doi: 10.1021/acs.chemrestox.3c00345. Epub 2024 Jan 10. Chem Res Toxicol. 2024. PMID: 38198604 Review.

10

Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA.

Housh K, Jha JS, Haldar T, Amin SBM, Islam T, Wallace A, Gomina A, Guo X, Nel C, Wyatt JW, Gates KS. Housh K, et al. Among authors: gates ks. DNA Repair (Amst). 2021 Feb;98:103029. doi: 10.1016/j.dnarep.2020.103029. Epub 2020 Dec 24. DNA Repair (Amst). 2021. PMID: 33385969 Free PMC article. Review.

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