Stephenson AA - Search Results

1

Conformational transitions of Streptococcus pyogenes Cas9 induced by salt and single-guide RNA binding.

He Y, Zalenski N, Stephenson AA, Raper AT, Ghimire C, Suo Z. He Y, et al. Among authors: stephenson aa. J Biol Chem. 2024 Dec 21:108120. doi: 10.1016/j.jbc.2024.108120. Online ahead of print. J Biol Chem. 2024. PMID: 39716488 Free article.

2

Functional Insights Revealed by the Kinetic Mechanism of CRISPR/Cas9.

Raper AT, Stephenson AA, Suo Z. Raper AT, et al. Among authors: stephenson aa. J Am Chem Soc. 2018 Feb 28;140(8):2971-2984. doi: 10.1021/jacs.7b13047. Epub 2018 Feb 19. J Am Chem Soc. 2018. PMID: 29442507

3

Sharpening the Scissors: Mechanistic Details of CRISPR/Cas9 Improve Functional Understanding and Inspire Future Research.

Raper AT, Stephenson AA, Suo Z. Raper AT, et al. Among authors: stephenson aa. J Am Chem Soc. 2018 Sep 12;140(36):11142-11152. doi: 10.1021/jacs.8b05469. Epub 2018 Aug 30. J Am Chem Soc. 2018. PMID: 30160947 Review.

4

The inhibitor of κB kinase β (IKKβ) phosphorylates IκBα twice in a single binding event through a sequential mechanism.

Stephenson AA, Taggart DJ, Xu G, Fowler JD, Wu H, Suo Z. Stephenson AA, et al. J Biol Chem. 2023 Jan;299(1):102796. doi: 10.1016/j.jbc.2022.102796. Epub 2022 Dec 14. J Biol Chem. 2023. PMID: 36528060 Free PMC article.

5

Design, synthesis, and evaluation of liver-specific gemcitabine prodrugs for potential treatment of hepatitis C virus infection and hepatocellular carcinoma.

Stephenson AA, Cao S, Taggart DJ, Vyavahare VP, Suo Z. Stephenson AA, et al. Eur J Med Chem. 2021 Mar 5;213:113135. doi: 10.1016/j.ejmech.2020.113135. Epub 2021 Jan 5. Eur J Med Chem. 2021. PMID: 33454548

6

Noncatalytic, N-terminal Domains of DNA Polymerase Lambda Affect Its Cellular Localization and DNA Damage Response.

Stephenson AA, Taggart DJ, Suo Z. Stephenson AA, et al. Chem Res Toxicol. 2017 May 15;30(5):1240-1249. doi: 10.1021/acs.chemrestox.7b00067. Epub 2017 Apr 13. Chem Res Toxicol. 2017. PMID: 28380295 Free PMC article.

7

Bidirectional Degradation of DNA Cleavage Products Catalyzed by CRISPR/Cas9.

Stephenson AA, Raper AT, Suo Z. Stephenson AA, et al. J Am Chem Soc. 2018 Mar 14;140(10):3743-3750. doi: 10.1021/jacs.7b13050. Epub 2018 Feb 20. J Am Chem Soc. 2018. PMID: 29461055

8

CRISPR-Cas9 homology-independent targeted integration of exons 1-19 restores full-length dystrophin in mice.

Stephenson AA, Nicolau S, Vetter TA, Dufresne GP, Frair EC, Sarff JE, Wheeler GL, Kelly BJ, White P, Flanigan KM. Stephenson AA, et al. Mol Ther Methods Clin Dev. 2023 Aug 18;30:486-499. doi: 10.1016/j.omtm.2023.08.009. eCollection 2023 Sep 14. Mol Ther Methods Clin Dev. 2023. PMID: 37706184 Free PMC article.

9

Gene editing and modulation for Duchenne muscular dystrophy.

Stephenson AA, Flanigan KM. Stephenson AA, et al. Prog Mol Biol Transl Sci. 2021;182:225-255. doi: 10.1016/bs.pmbts.2021.01.029. Epub 2021 Mar 3. Prog Mol Biol Transl Sci. 2021. PMID: 34175043 Review.

10

Investigation into the linearity of the Roche c 702 carbamazepine assay.

Stephenson AA, Robinson CG, Marrington R, Hawley JM. Stephenson AA, et al. Ann Clin Biochem. 2024 Oct 17:45632241292510. doi: 10.1177/00045632241292510. Online ahead of print. Ann Clin Biochem. 2024. PMID: 39367537

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