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Analogues of the anti-malaria drug mefloquine have broad spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection.
Guin S, Montoya MC, Wang X, Zarnowski R, Andes DR, Meyers MJ, Williams NS, Krysan DJ. Guin S, et al. Among authors: andes dr. bioRxiv [Preprint]. 2024 Aug 30:2024.08.29.610379. doi: 10.1101/2024.08.29.610379. bioRxiv. 2024. Update in: Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0130124. doi: 10.1128/aac.01301-24 PMID: 39257751 Free PMC article. Updated. Preprint.
Addendum: A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.
MacAlpine J, Daniel-Ivad M, Liu Z, Yano J, Revie NM, Todd RT, Stogios PJ, Sanchez H, O'Meara TR, Tompkins TA, Savchenko A, Selmecki A, Veri AO, Andes DR, Fidel PL Jr, Robbins N, Nodwell J, Whitesell L, Cowen LE. MacAlpine J, et al. Among authors: andes dr. Nat Commun. 2024 Aug 1;15(1):6440. doi: 10.1038/s41467-024-50740-z. Nat Commun. 2024. PMID: 39090082 Free PMC article. No abstract available.
Systematic analysis of the Candida albicans kinome reveals environmentally contingent protein kinase-mediated regulation of filamentation and biofilm formation in vitro and in vivo.
Kramara J, Kim M-J, Ollinger TL, Ristow LC, Wakade RS, Zarnowski R, Wellington M, Andes DR, Mitchell AG, Krysan DJ. Kramara J, et al. Among authors: andes dr. mBio. 2024 Aug 14;15(8):e0124924. doi: 10.1128/mbio.01249-24. Epub 2024 Jul 1. mBio. 2024. PMID: 38949302 Free PMC article.
Metabolic reprogramming during Candida albicans planktonic-biofilm transition is modulated by the transcription factors Zcf15 and Zcf26.
Rai LS, Chauvel M, Sanchez H, van Wijlick L, Maufrais C, Cokelaer T, Sertour N, Legrand M, Sanyal K, Andes DR, Bachellier-Bassi S, d'Enfert C. Rai LS, et al. Among authors: andes dr. PLoS Biol. 2024 Jun 21;22(6):e3002693. doi: 10.1371/journal.pbio.3002693. eCollection 2024 Jun. PLoS Biol. 2024. PMID: 38905306 Free PMC article.
SARS-CoV-2 Viral Load in the Nasopharynx at Time of First Infection Among Unvaccinated Individuals: A Secondary Cross-Protocol Analysis of 4 Randomized Trials.
Fisher LH, Kee JJ, Liu A, Espinosa CM, Randhawa AK, Ludwig J, Magaret CA, Robinson ST, Gilbert PB, Hyrien O, Kublin JG, Rouphael N, Falsey AR, Sobieszczyk ME, El Sahly HM, Grinsztejn B, Gray GE, Kotloff KL, Gay CL, Leav B, Hirsch I, Struyf F, Dunkle LM, Neuzil KM, Corey L, Huang Y, Goepfert PA, Walsh SR, Baden LR, Janes H; COVID-19 Prevention Network (CoVPN). Fisher LH, et al. JAMA Netw Open. 2024 May 1;7(5):e2412835. doi: 10.1001/jamanetworkopen.2024.12835. JAMA Netw Open. 2024. PMID: 38780941 Free PMC article.
Biofilm-associated metabolism via ERG251 in Candida albicans.
Xiong L, Pereira De Sa N, Zarnowski R, Huang MY, Mota Fernandes C, Lanni F, Andes DR, Del Poeta M, Mitchell AP. Xiong L, et al. Among authors: andes dr. PLoS Pathog. 2024 May 13;20(5):e1012225. doi: 10.1371/journal.ppat.1012225. eCollection 2024 May. PLoS Pathog. 2024. PMID: 38739655 Free PMC article.
212 results