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Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains.
Lederberg OL, Yan NL, Sanchez J, Ren W, Ash C, Wilkens SJ, Qiu H, Qin B, Grant VH, Jackman AB, Stanfield RL, Wilson IA, Petrassi HM, Rhoades D, Kelly JW. Lederberg OL, et al. Among authors: wilson ia. J Med Chem. 2024 Dec 12;67(23):21070-21105. doi: 10.1021/acs.jmedchem.4c01773. Epub 2024 Dec 3. J Med Chem. 2024. PMID: 39626211
Plant-produced SARS-CoV-2 antibody engineered towards enhanced potency and in vivo efficacy.
de Taeye SW, Faye L, Morel B, Schriek AI, Umotoy JC, Yuan M, Kuzmina NA, Turner HL, Zhu X, Grünwald-Gruber C, Poniman M, Burger JA, Caniels TG, Fitchette AC, Desgagnés R, Stordeur V, Mirande L, Beauverger G, de Bree G, Ozorowski G, Ward AB, Wilson IA, Bukreyev A, Sanders RW, Vezina LP, Beaumont T, van Gils MJ, Gomord V. de Taeye SW, et al. Among authors: wilson ia. Plant Biotechnol J. 2024 Nov 19. doi: 10.1111/pbi.14458. Online ahead of print. Plant Biotechnol J. 2024. PMID: 39563066 Free article.
Cladophorol-A is an inhibitor of cyclic GMP-AMP synthase.
Kissai M, Chin EN, Martínez-Peña F, Sulpizio A, Stout EP, Usui I, Barmare F, Sanchez B, Esquenazi E, Stanfield RL, Wilson IA, Lairson LL. Kissai M, et al. Among authors: wilson ia. Bioorg Med Chem Lett. 2025 Jan 1;115:130007. doi: 10.1016/j.bmcl.2024.130007. Epub 2024 Nov 7. Bioorg Med Chem Lett. 2025. PMID: 39521150
Reshaping the tumor microenvironment by degrading glycoimmune checkpoints Siglec-7 and -9.
Wang C, Hou Y, Zak J, Zheng Q, McCord KA, Wu M, Zhang D, Chung S, Shi Y, Ye J, Zhao Y, Hajjar S, Wilson IA, Paulson JC, Teijaro JR, Zhou X, Sharpless KB, Macauley MS, Wu P. Wang C, et al. Among authors: wilson ia. bioRxiv [Preprint]. 2024 Oct 12:2024.10.11.617879. doi: 10.1101/2024.10.11.617879. bioRxiv. 2024. PMID: 39416090 Free PMC article. Preprint.
Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire.
Altman PX, Ozorowski G, Stanfield RL, Haakenson J, Appel M, Parren M, Lee WH, Sang H, Woehl J, Saye-Francisco K, Sewall LM, Joyce C, Song G, Porter K, Landais E, Andrabi R, Wilson IA, Ward AB, Mwangi W, Smider VV, Burton DR, Sok D. Altman PX, et al. Among authors: wilson ia. PLoS Pathog. 2024 Sep 9;20(9):e1012042. doi: 10.1371/journal.ppat.1012042. eCollection 2024 Sep. PLoS Pathog. 2024. PMID: 39250525 Free PMC article.
936 results