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Page 1
Patient-Derived Xenografts of Triple-Negative Breast Cancer Enable Deconvolution and Prediction of Chemotherapy Responses.
Lei JT, Dobrolecki LE, Huang C, Srinivasan RR, Vasaikar SV, Lewis AN, Sallas C, Zhao N, Cao J, Landua JD, Moon CI, Liao Y, Hilsenbeck SG, Osborne CK, Rimawi MF, Ellis MJ, Petrosyan V, Wen B, Li K, Saltzman AB, Jain A, Malovannaya A, Wulf GM, Marangoni E, Li S, Kraushaar DC, Wang T, Damodaran S, Zheng X, Meric-Bernstam F, Echeverria GV, Anurag M, Chen X, Welm BE, Welm AL, Zhang B, Lewis MT. Lei JT, et al. Among authors: lewis mt. bioRxiv [Preprint]. 2024 Dec 12:2024.12.09.627518. doi: 10.1101/2024.12.09.627518. bioRxiv. 2024. PMID: 39713418 Free PMC article. Preprint.
Three-dimensional analysis of mitochondria in a patient-derived xenograft model of triple negative breast cancer reveals mitochondrial network remodeling following chemotherapy treatments.
Berner MJ, Beasley HK, Vue Z, Lane A, Vang L, Baek ML, Marshall AG, Killion M, Zeleke F, Shao B, Parker D, Peterson A, Rhoades JS, Scudese E, Dobrolecki LE, Lewis MT, Hinton A Jr, Echeverria GV. Berner MJ, et al. Among authors: lewis mt. bioRxiv [Preprint]. 2024 Sep 9:2024.09.09.611245. doi: 10.1101/2024.09.09.611245. bioRxiv. 2024. PMID: 39314272 Free PMC article. Preprint.
Polyploid cancer cells reveal signatures of chemotherapy resistance.
Schmidt MJ, Naghdloo A, Prabakar RK, Kamal M, Cadaneanu R, Garraway IP, Lewis M, Aparicio A, Zurita-Saavedra A, Corn P, Kuhn P, Pienta KJ, Amend SR, Hicks J. Schmidt MJ, et al. bioRxiv [Preprint]. 2024 Aug 23:2024.08.19.608632. doi: 10.1101/2024.08.19.608632. bioRxiv. 2024. Update in: Oncogene. 2024 Nov 22. doi: 10.1038/s41388-024-03212-z PMID: 39229204 Free PMC article. Updated. Preprint.
A precision oncology-focused deep learning framework for personalized selection of cancer therapy.
Sederman C, Yang CH, Cortes-Sanchez E, Di Sera T, Huang X, Scherer SD, Zhao L, Chu Z, White ER, Atkinson A, Wagstaff J, Varley KE, Lewis MT, Qiao Y, Welm BE, Welm AL, Marth GT. Sederman C, et al. Among authors: lewis mt. bioRxiv [Preprint]. 2024 Dec 16:2024.12.12.628190. doi: 10.1101/2024.12.12.628190. bioRxiv. 2024. PMID: 39763776 Free PMC article. Preprint.
UBA1 inhibition sensitizes cancer cells to PARP inhibitors.
Awasthi S, Dobrolecki LE, Sallas C, Zhang X, Li Y, Khazaei S, Ghosh S, Jeter CR, Liu J, Mills GB, Westin SN, Lewis MT, Peng W, Sood AK, Yap TA, Yi SS, McGrail DJ, Sahni N. Awasthi S, et al. Among authors: lewis mt. Cell Rep Med. 2024 Dec 17;5(12):101834. doi: 10.1016/j.xcrm.2024.101834. Epub 2024 Dec 2. Cell Rep Med. 2024. PMID: 39626673 Free PMC article.
IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer.
Xu L, Peng F, Luo Q, Ding Y, Yuan F, Zheng L, He W, Zhang SS, Fu X, Liu J, Mutlu AS, Wang S, Nehring RB, Li X, Tang Q, Li C, Lv X, Dobrolecki LE, Zhang W, Han D, Zhao N, Jaehnig E, Wang J, Wu W, Graham DA, Li Y, Chen R, Peng W, Chen Y, Catic A, Zhang Z, Zhang B, Mustoe AM, Koong AC, Miles G, Lewis MT, Wang MC, Rosenberg SM, O'Malley BW, Westbrook TF, Xu H, Zhang XH, Osborne CK, Li JB, Ellis MJ, Rimawi MF, Rosen JM, Chen X. Xu L, et al. Among authors: lewis mt. Cell. 2024 Dec 12;187(25):7248-7266.e34. doi: 10.1016/j.cell.2024.09.032. Epub 2024 Oct 16. Cell. 2024. PMID: 39419025
A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis.
White BS, Woo XY, Koc S, Sheridan T, Neuhauser SB, Wang S, Evrard YA, Chen L, Foroughi Pour A, Landua JD, Mashl RJ, Davies SR, Fang B, Raso MG, Evans KW, Bailey MH, Chen Y, Xiao M, Rubinstein JC, Sanderson BJ, Lloyd MW, Domanskyi S, Dobrolecki LE, Fujita M, Fujimoto J, Xiao G, Fields RC, Mudd JL, Xu X, Hollingshead MG, Jiwani S, Acevedo S; PDXNet Consortium; Davis-Dusenbery BN, Robinson PN, Moscow JA, Doroshow JH, Mitsiades N, Kaochar S, Pan CX, Carvajal-Carmona LG, Welm AL, Welm BE, Govindan R, Li S, Davies MA, Roth JA, Meric-Bernstam F, Xie Y, Herlyn M, Ding L, Lewis MT, Bult CJ, Dean DA 2nd, Chuang JH. White BS, et al. Among authors: lewis mt. Cancer Res. 2024 Jul 2;84(13):2060-2072. doi: 10.1158/0008-5472.CAN-23-1349. Cancer Res. 2024. PMID: 39082680 Free PMC article.
Assessment of Patient-Derived Xenograft Growth and Antitumor Activity: The NCI PDXNet Consensus Recommendations.
Meric-Bernstam F, Lloyd MW, Koc S, Evrard YA, McShane LM, Lewis MT, Evans KW, Li D, Rubinstein L, Welm A, Dean DA 2nd, Srivastava A, Grover JW, Ha MJ, Chen H, Huang X, Varadarajan K, Wang J, Roth JA, Welm B, Govinden R, Ding L, Kaochar S, Mitsiades N, Carvajal-Carmona L, Herylyn M, Davies MA, Shapiro GI, Fields R, Trevino JG, Harrell JC; NCI PDXNet Consortium; Doroshow JH, Chuang JH, Moscow JA. Meric-Bernstam F, et al. Among authors: lewis mt. Mol Cancer Ther. 2024 Jul 2;23(7):924-938. doi: 10.1158/1535-7163.MCT-23-0471. Mol Cancer Ther. 2024. PMID: 38641411 Free PMC article.
A novel treatment strategy utilizing panobinostat for high-risk and treatment-refractory hepatoblastoma.
Espinoza AF, Patel RH, Patel KR, Badachhape AA, Whitlock R, Srivastava RK, Govindu SR, Duong A, Kona A, Kureti P, Armbruster B, Kats D, Srinivasan RR, Dobrolecki LE, Yu X, Najaf Panah MJ, Zorman B, Sarabia SF, Urbicain M, Major A, Bissig KD, Keller C, Lewis MT, Heczey A, Sumazin P, López-Terrada DH, Woodfield SE, Vasudevan SA. Espinoza AF, et al. Among authors: lewis mt. J Hepatol. 2024 Apr;80(4):610-621. doi: 10.1016/j.jhep.2024.01.003. Epub 2024 Jan 17. J Hepatol. 2024. PMID: 38242326
187 results