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Improving design and normalization of multiplex proteomics study.
Fang H, Shih MC, Jiang L, da Veiga Leprevost F, Jian R, Chan J, Nesvizhskii AI, Snyder MP, Tang H. Fang H, et al. Among authors: chan j. bioRxiv [Preprint]. 2024 Dec 10:2024.12.05.627093. doi: 10.1101/2024.12.05.627093. bioRxiv. 2024. PMID: 39713300 Free PMC article. Preprint.
Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis.
Esplin ED, Hanson C, Wu S, Horning AM, Barapour N, Nevins SA, Jiang L, Contrepois K, Lee H, Guha TK, Hu Z, Laquindanum R, Mills MA, Chaib H, Chiu R, Jian R, Chan J, Ellenberger M, Becker WR, Bahmani B, Khan A, Michael B, Weimer AK, Esplin DG, Shen J, Lancaster S, Monte E, Karathanos TV, Ladabaum U, Longacre TA, Kundaje A, Curtis C, Greenleaf WJ, Ford JM, Snyder MP. Esplin ED, et al. Among authors: chan j. Nat Cancer. 2024 Nov;5(11):1737-1753. doi: 10.1038/s43018-024-00831-z. Epub 2024 Oct 30. Nat Cancer. 2024. PMID: 39478120 Free PMC article.
The impact of rare variation on gene expression across tissues.
Li X, Kim Y, Tsang EK, Davis JR, Damani FN, Chiang C, Hess GT, Zappala Z, Strober BJ, Scott AJ, Li A, Ganna A, Bassik MC, Merker JD; GTEx Consortium; Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group; Statistical Methods groups—Analysis Working Group; Enhancing GTEx (eGTEx) groups; NIH Common Fund; NIH/NCI; NIH/NHGRI; NIH/NIMH; NIH/NIDA; Biospecimen Collection Source Site—NDRI; Biospecimen Collection Source Site—RPCI; Biospecimen Core Resource—VARI; Brain Bank Repository—University of Miami Brain Endowment Bank; Leidos Biomedical—Project Management; ELSI Study; Genome Browser Data Integration &Visualization—EBI; Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz; Hall IM, Battle A, Montgomery SB. Li X, et al. Nature. 2017 Oct 11;550(7675):239-243. doi: 10.1038/nature24267. Nature. 2017. PMID: 29022581 Free PMC article.
Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines.
Wei SC, Cantor AJ, Walleshauser J, Mepani R, Melton K, Bans A, Khekare P, Gupta S, Wang J, Soares C, Kiwan R, Lee J, McCawley S, Jani V, Leong WI, Shahi PK, Chan J, Boivin P, Otoupal P, Pattnaik BR, Gamm DM, Saha K, Gowen BG, Haak-Frendscho M, Janatpour MJ, Silverman AP. Wei SC, et al. Among authors: chan j. bioRxiv [Preprint]. 2024 Dec 30:2024.12.30.630799. doi: 10.1101/2024.12.30.630799. bioRxiv. 2024. PMID: 39803585 Free PMC article. Preprint.
Development of novel GI-centric prostaglandin E2 receptor type 4 (EP4) agonist prodrugs as treatment for ulcerative colitis and other intestinal inflammatory diseases.
Kantham S, Yu H, Cantelli CR, Chen G, Ma C, Chan JJ, Yang H, Tsai K, Lassueur K, Vallance BA, Jacobson K, Young RN. Kantham S, et al. Among authors: chan jj. Bioorg Med Chem Lett. 2025 Jan 8:130093. doi: 10.1016/j.bmcl.2025.130093. Online ahead of print. Bioorg Med Chem Lett. 2025. PMID: 39793629
Bidirectional histone monoaminylation dynamics regulate neural rhythmicity.
Zheng Q, Weekley BH, Vinson DA, Zhao S, Bastle RM, Thompson RE, Stransky S, Ramakrishnan A, Cunningham AM, Dutta S, Chan JC, Di Salvo G, Chen M, Zhang N, Wu J, Fulton SL, Kong L, Wang H, Zhang B, Vostal L, Upad A, Dierdorff L, Shen L, Molina H, Sidoli S, Muir TW, Li H, David Y, Maze I. Zheng Q, et al. Among authors: chan jc. Nature. 2025 Jan 8. doi: 10.1038/s41586-024-08371-3. Online ahead of print. Nature. 2025. PMID: 39779849
9,998 results