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Covalent-fragment screening identifies selective inhibitors of multiple Staphylococcus aureus serine hydrolases important for growth and biofilm formation.
Bogyo M, Upadhyay T, Woods E, Ahator S, Julin K, Faucher F, Hollander M, Pedowitz N, Abegg D, Hammond I, Eke I, Wang S, Chen S, Bennett J, Jo J, Lentz C, Adibekian A, Fellner M. Bogyo M, et al. Among authors: adibekian a. Res Sq [Preprint]. 2024 Dec 13:rs.3.rs-5494070. doi: 10.21203/rs.3.rs-5494070/v1. Res Sq. 2024. PMID: 39711551 Free PMC article. Preprint.
Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets.
Bennett JM, Narwal SK, Kabeche S, Abegg D, Hackett F, Yeo T, Li VL, Muir RK, Faucher FF, Lovell S, Blackman MJ, Adibekian A, Yeh E, Fidock DA, Bogyo M. Bennett JM, et al. Among authors: adibekian a. bioRxiv [Preprint]. 2024 Jan 11:2024.01.11.575224. doi: 10.1101/2024.01.11.575224. bioRxiv. 2024. Update in: Cell Chem Biol. 2024 Sep 19;31(9):1714-1728.e10. doi: 10.1016/j.chembiol.2024.07.006 PMID: 38260474 Free PMC article. Updated. Preprint.
Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets.
Bennett JM, Narwal SK, Kabeche S, Abegg D, Thathy V, Hackett F, Yeo T, Li VL, Muir R, Faucher F, Lovell S, Blackman MJ, Adibekian A, Yeh E, Fidock DA, Bogyo M. Bennett JM, et al. Among authors: adibekian a. Cell Chem Biol. 2024 Sep 19;31(9):1714-1728.e10. doi: 10.1016/j.chembiol.2024.07.006. Epub 2024 Aug 12. Cell Chem Biol. 2024. PMID: 39137783
Chaperone-directed ribosome repair after oxidative damage.
Yang YM, Jung Y, Abegg D, Adibekian A, Carroll KS, Karbstein K. Yang YM, et al. Among authors: adibekian a. Mol Cell. 2023 May 4;83(9):1527-1537.e5. doi: 10.1016/j.molcel.2023.03.030. Epub 2023 Apr 21. Mol Cell. 2023. PMID: 37086725 Free PMC article.
Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera.
Tong Y, Zhang P, Yang X, Liu X, Zhang J, Grudniewska M, Jung I, Abegg D, Liu J, Childs-Disney JL, Gibaut QMR, Haniff HS, Adibekian A, Mouradian MM, Disney MD. Tong Y, et al. Among authors: adibekian a. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2306682120. doi: 10.1073/pnas.2306682120. Epub 2024 Jan 5. Proc Natl Acad Sci U S A. 2024. PMID: 38181056 Free PMC article.
Programming inactive RNA-binding small molecules into bioactive degraders.
Tong Y, Lee Y, Liu X, Childs-Disney JL, Suresh BM, Benhamou RI, Yang C, Li W, Costales MG, Haniff HS, Sievers S, Abegg D, Wegner T, Paulisch TO, Lekah E, Grefe M, Crynen G, Van Meter M, Wang T, Gibaut QMR, Cleveland JL, Adibekian A, Glorius F, Waldmann H, Disney MD. Tong Y, et al. Among authors: adibekian a. Nature. 2023 Jun;618(7963):169-179. doi: 10.1038/s41586-023-06091-8. Epub 2023 May 24. Nature. 2023. PMID: 37225982 Free PMC article.
84 results