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Page 1
Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention.
Nie Z, Bonnert R, Tsien J, Deng X, Higgs C, El Mazouni F, Zhang X, Li R, Ho N, Feher V, Paulsen J, Shackleford DM, Katneni K, Chen G, Ng ACF, McInerney M, Wang W, Saunders J, Collins D, Yan D, Li P, Campbell M, Patil R, Ghoshal A, Mondal P, Kundu A, Chittimalla R, Mahadeva M, Kokkonda S, White J, Das R, Mukherjee P, Angulo-Barturen I, Jiménez-Díaz MB, Malmstrom R, Lawrenz M, Rodriguez-Granillo A, Rathod PK, Tomchick DR, Palmer MJ, Laleu B, Qin T, Charman SA, Phillips MA. Nie Z, et al. Among authors: shackleford dm. J Med Chem. 2024 Dec 22. doi: 10.1021/acs.jmedchem.4c02394. Online ahead of print. J Med Chem. 2024. PMID: 39710971
Single-Dose Drug Development Candidate for Schistosomiasis.
Leas DA, Keiser J, Charman SA, Shackleford DM, Jones JO, Campbell M, Chen G, Katneni K, Patil R, Hu M, Pham T, Häberli C, Schulze TT, Neville AJ, Wang X, Dong Y, Davis PH, Vennerstrom JL. Leas DA, et al. Among authors: shackleford dm. ACS Infect Dis. 2024 Nov 8;10(11):3963-3972. doi: 10.1021/acsinfecdis.4c00677. Epub 2024 Oct 18. ACS Infect Dis. 2024. PMID: 39423362
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria.
Lawong A, Gahalawat S, Ray S, Ho N, Han Y, Ward KE, Deng X, Chen Z, Kumar A, Xing C, Hosangadi V, Fairhurst KJ, Tashiro K, Liszczak G, Shackleford DM, Katneni K, Chen G, Saunders J, Crighton E, Casas A, Robinson JJ, Imlay LS, Zhang X, Lemoff A, Zhao Z, Angulo-Barturen I, Jiménez-Díaz MB, Wittlin S, Campbell SF, Fidock DA, Laleu B, Charman SA, Ready JM, Phillips MA. Lawong A, et al. Among authors: shackleford dm. Cell Chem Biol. 2024 Aug 15;31(8):1503-1517.e19. doi: 10.1016/j.chembiol.2024.07.001. Epub 2024 Jul 30. Cell Chem Biol. 2024. PMID: 39084225
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1.
Braillard S, Keenan M, Breese KJ, Heppell J, Abbott M, Islam R, Shackleford DM, Katneni K, Crighton E, Chen G, Patil R, Lee G, White KL, Carvalho S, Wall RJ, Chemi G, Zuccotto F, González S, Marco M, Deakyne J, Standing D, Brunori G, Lyon JJ, Castañeda-Casado P, Camino I, Martinez Martinez MS, Zulfiqar B, Avery VM, Feijens PB, Van Pelt N, Matheeussen A, Hendrickx S, Maes L, Caljon G, Yardley V, Wyllie S, Charman SA, Chatelain E. Braillard S, et al. Among authors: shackleford dm. Sci Transl Med. 2023 Dec 13;15(726):eadh9902. doi: 10.1126/scitranslmed.adh9902. Epub 2023 Dec 13. Sci Transl Med. 2023. PMID: 38091406 Free PMC article.
Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR.
Jörg M, van der Westhuizen ET, Lu Y, Christopher Choy KH, Shackleford DM, Khajehali E, Tobin AB, Thal DM, Capuano B, Christopoulos A, Valant C, Scammells PJ. Jörg M, et al. Among authors: shackleford dm. Eur J Med Chem. 2023 Oct 5;258:115588. doi: 10.1016/j.ejmech.2023.115588. Epub 2023 Jul 1. Eur J Med Chem. 2023. PMID: 37423123 Free PMC article.
PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective.
Orozco Morales ML, Rinaldi CA, de Jong E, Lansley SM, Gummer JPA, Olasz B, Nambiar S, Hope DE, Casey TH, Lee YCG, Leslie C, Nealon G, Shackleford DM, Powell AK, Grimaldi M, Balaguer P, Zemek RM, Bosco A, Piggott MJ, Vrielink A, Lake RA, Lesterhuis WJ. Orozco Morales ML, et al. Among authors: shackleford dm. iScience. 2021 Dec 4;25(1):103571. doi: 10.1016/j.isci.2021.103571. eCollection 2022 Jan 21. iScience. 2021. PMID: 34984327 Free PMC article.
Correction to: The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease.
Finkelstein DI, Billings JL, Adlard PA, Ayton S, Sedjahtera A, Masters CL, Wilkins S, Shackleford DM, Charman SA, Bal W, Zawisza IA, Kurowska E, Gundlach AL, Ma S, Bush AI, Hare DJ, Doble PA, Crawford S, Gautier ECL, Parsons J, Huggins P, Barnham KJ, Cherny RA. Finkelstein DI, et al. Among authors: shackleford dm. Acta Neuropathol Commun. 2021 Sep 29;9(1):161. doi: 10.1186/s40478-021-01258-8. Acta Neuropathol Commun. 2021. PMID: 34588001 Free PMC article. No abstract available.
Development of [18F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease.
Wong SW, Vivash L, Mudududdla R, Nguyen N, Hermans SJ, Shackleford DM, Field J, Xue L, Aprico A, Hancock NC, Haskali M, Stashko MA, Frye SV, Wang X, Binder MD, Ackermann U, Parker MW, Kilpatrick TJ, Baell JB. Wong SW, et al. Among authors: shackleford dm. Eur J Med Chem. 2021 Dec 15;226:113822. doi: 10.1016/j.ejmech.2021.113822. Epub 2021 Sep 4. Eur J Med Chem. 2021. PMID: 34563964
85 results