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Pathogenic TNNI1 variants disrupt sarcomere contractility resulting in hypo- and hypercontractile muscle disease.
Donkervoort S, van de Locht M, Ronchi D, Reunert J, McLean CA, Zaki M, Orbach R, de Winter JM, Conijn S, Hoomoedt D, Neto OLA, Magri F, Viaene AN, Foley AR, Gorokhova S, Bolduc V, Hu Y, Acquaye N, Napoli L, Park JH, Immadisetty K, Miles LB, Essawi M, McModie S, Ferreira LF, Zanotti S, Neuhaus SB, Medne L, ElBagoury N, Johnson KR, Zhang Y, Laing NG, Davis MR, Bryson-Richardson RJ, Hwee DT, Hartman JJ, Malik FI, Kekenes-Huskey PM, Comi GP, Sharaf-Eldin W, Marquardt T, Ravenscroft G, Bönnemann CG, Ottenheijm CAC. Donkervoort S, et al. Among authors: kekenes huskey pm. Sci Transl Med. 2024 Apr 3;16(741):eadg2841. doi: 10.1126/scitranslmed.adg2841. Epub 2024 Apr 3. Sci Transl Med. 2024. PMID: 38569017 Free article.
Molecular Insights into the MLCK Activation by CaM.
Fang X, Bogdanov V, Davis JP, Kekenes-Huskey PM. Fang X, et al. Among authors: kekenes huskey pm. J Chem Inf Model. 2023 Dec 11;63(23):7487-7498. doi: 10.1021/acs.jcim.3c00954. Epub 2023 Nov 28. J Chem Inf Model. 2023. PMID: 38016288 Free PMC article.
Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2.
Rodriguez Garcia M, Schmeckpeper J, Landim-Vieira M, Coscarella IL, Fang X, Ma W, Spran PA, Yuan S, Qi L, Kahmini AR, Shoemaker MB, Atkinson JB, Kekenes-Huskey PM, Irving TC, Chase PB, Knollmann BC, Pinto JR. Rodriguez Garcia M, et al. Among authors: kekenes huskey pm. Int J Mol Sci. 2023 Sep 26;24(19):14572. doi: 10.3390/ijms241914572. Int J Mol Sci. 2023. PMID: 37834023 Free PMC article.
Programming Cell-Derived Vesicles with Enhanced Immunomodulatory Properties.
Neupane KR, Ramon GS, Harvey B, Chun B, Aryal SP, Masud AA, McCorkle JR, Kolesar JM, Kekenes-Huskey PM, Richards CI. Neupane KR, et al. Among authors: kekenes huskey pm. Adv Healthc Mater. 2023 Oct;12(27):e2301163. doi: 10.1002/adhm.202301163. Epub 2023 Jul 9. Adv Healthc Mater. 2023. PMID: 37377147 Free PMC article.
Human disease-associated calmodulin mutations alter calcineurin function through multiple mechanisms.
Williams RB, Alam Afsar MN, Tikunova S, Kou Y, Fang X, Somarathne RP, Gyawu RF, Knotts GM, Agee TA, Garcia SA, Losordo LD, Fitzkee NC, Kekenes-Huskey PM, Davis JP, Johnson CN. Williams RB, et al. Among authors: kekenes huskey pm. Cell Calcium. 2023 Jul;113:102752. doi: 10.1016/j.ceca.2023.102752. Epub 2023 May 10. Cell Calcium. 2023. PMID: 37245392 Free PMC article.
Purinoreceptors and ectonucleotidases control ATP-induced calcium waveforms and calcium-dependent responses in microglia: Roles of P2 receptors and CD39 in ATP-stimulated microglia.
Chun BJ, Aryal SP, Varughese P, Sun B, Bruno JA, Richards CI, Bachstetter AD, Kekenes-Huskey PM. Chun BJ, et al. Among authors: kekenes huskey pm. Front Physiol. 2023 Jan 9;13:1037417. doi: 10.3389/fphys.2022.1037417. eCollection 2022. Front Physiol. 2023. PMID: 36699679 Free PMC article.
57 results