Hu D - Search Results

1

BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson's disease.

Jishi A, Hu D, Shang Y, Wang R, Gunzler SA, Qi X. Jishi A, et al. Among authors: hu d. Acta Neuropathol Commun. 2024 Dec 21;12(1):198. doi: 10.1186/s40478-024-01915-8. Acta Neuropathol Commun. 2024. PMID: 39709505 Free PMC article.

2

Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.

Hu D, Sun X, Liao X, Zhang X, Zarabi S, Schimmer A, Hong Y, Ford C, Luo Y, Qi X. Hu D, et al. Acta Neuropathol. 2019 Jun;137(6):939-960. doi: 10.1007/s00401-019-01993-2. Epub 2019 Mar 15. Acta Neuropathol. 2019. PMID: 30877431 Free PMC article.

3

Using induced pluripotent stem cell neuronal models to study neurodegenerative diseases.

Zhang X, Hu D, Shang Y, Qi X. Zhang X, et al. Among authors: hu d. Biochim Biophys Acta Mol Basis Dis. 2020 Apr 1;1866(4):165431. doi: 10.1016/j.bbadis.2019.03.004. Epub 2019 Mar 18. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 30898538 Free PMC article. Review.

4

VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.

Guo X, Sun X, Hu D, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi AU, Luo Y, Mochly-Rosen D, Qi X. Guo X, et al. Among authors: hu d. Nat Commun. 2016 Aug 26;7:12646. doi: 10.1038/ncomms12646. Nat Commun. 2016. PMID: 27561680 Free PMC article.

5

ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.

Zhao Y, Sun X, Hu D, Prosdocimo DA, Hoppel C, Jain MK, Ramachandran R, Qi X. Zhao Y, et al. Among authors: hu d. Nat Commun. 2019 Mar 26;10(1):1371. doi: 10.1038/s41467-019-09291-x. Nat Commun. 2019. PMID: 30914652 Free PMC article.

6

Measuring Drp1 Activity in Mitochondrial Fission In Vivo.

Hu D, Qi X. Hu D, et al. Methods Mol Biol. 2020;2159:189-195. doi: 10.1007/978-1-0716-0676-6_14. Methods Mol Biol. 2020. PMID: 32529372 Free PMC article.

7

UPR^mt activation protects against MPP⁺-induced toxicity in a cell culture model of Parkinson's disease.

Hu D, Liu Z, Qi X. Hu D, et al. Biochem Biophys Res Commun. 2021 Sep 10;569:17-22. doi: 10.1016/j.bbrc.2021.06.079. Epub 2021 Jun 30. Biochem Biophys Res Commun. 2021. PMID: 34216993 Free PMC article.

8

Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.

Hu D, Sun X, Magpusao A, Fedorov Y, Thompson M, Wang B, Lundberg K, Adams DJ, Qi X. Hu D, et al. Nat Commun. 2021 Sep 6;12(1):5305. doi: 10.1038/s41467-021-25651-y. Nat Commun. 2021. PMID: 34489447 Free PMC article.

9

Mitochondrial Quality Control Strategies: Potential Therapeutic Targets for Neurodegenerative Diseases?

Hu D, Liu Z, Qi X. Hu D, et al. Front Neurosci. 2021 Nov 12;15:746873. doi: 10.3389/fnins.2021.746873. eCollection 2021. Front Neurosci. 2021. PMID: 34867159 Free PMC article. Review.

10

ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.

Zhao Y, Hu D, Wang R, Sun X, Ropelewski P, Hubler Z, Lundberg K, Wang Q, Adams DJ, Xu R, Qi X. Zhao Y, et al. Among authors: hu d. Nat Commun. 2022 Mar 2;13(1):1121. doi: 10.1038/s41467-022-28769-9. Nat Commun. 2022. PMID: 35236834 Free PMC article.

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