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Evaluating efflux pump inhibition in Staphylococcus aureus 1199B strain using thiadiazine-derived compounds: In vitro and in silico approaches.
Freitas PR, Araújo ACJ, Araújo IM, Almeida RS, Oliveira Borges JA, Lima CMG, Oliveira-Tintino CDM, Paulo CLR, Miranda GM, Araújo-Neto JB, Almeida-Bezerra JW, Nascimento IJDS, Araújo-Júnior JX, Silva-Júnior EFD, Aquino TM, Mendonca Junior FJB, Marinho ES, Santos HSD, Menezes IRA, Tintino SR, Coutinho HDM. Freitas PR, et al. Biochimie. 2024 Dec 19:S0300-9084(24)00313-4. doi: 10.1016/j.biochi.2024.12.009. Online ahead of print. Biochimie. 2024. PMID: 39708974
Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration.
Freitas PR, de Araújo ACJ, Araújo IM, de Almeida RS, Borges JAO, Paulo CLR, Oliveira-Tintino CDM, Miranda GM, Araújo-Neto JB, Nascimento IJS, Araújo-Júnior JX, Silva JMA, Balbino TCL, Silva-Júnior EF, Aquino TM, Mendonca-Junior FJB, Marinho ES, Santos HS, Lima CMG, Obaidullah AJ, Bin Emran T, Cunha FAB, Menezes IRA, Tintino SR, Coutinho HDM. Freitas PR, et al. Biomed Pharmacother. 2024 Oct;179:117291. doi: 10.1016/j.biopha.2024.117291. Epub 2024 Aug 14. Biomed Pharmacother. 2024. PMID: 39146766 Free article.
Terpenes as bacterial efflux pump inhibitors: A systematic review.
Dias KJSO, Miranda GM, Bessa JR, Araújo ACJ, Freitas PR, Almeida RS, Paulo CLR, Neto JBA, Coutinho HDM, Ribeiro-Filho J. Dias KJSO, et al. Among authors: freitas pr. Front Pharmacol. 2022 Oct 13;13:953982. doi: 10.3389/fphar.2022.953982. eCollection 2022. Front Pharmacol. 2022. PMID: 36313340 Free PMC article.
Potentiating-antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi-drug resistant (MDR) strains.
de Araújo ACJ, Freitas PR, Araújo IM, Siqueira GM, de Oliveira Borges JA, Alves DS, Miranda GM, Dos Santos Nascimento IJ, de Araújo-Júnior JX, da Silva-Júnior EF, de Aquino TM, Junior FJBM, Marinho ES, Dos Santos HS, Tintino SR, Coutinho HDM. de Araújo ACJ, et al. Among authors: freitas pr. Fundam Clin Pharmacol. 2024 Feb;38(1):84-98. doi: 10.1111/fcp.12950. Epub 2023 Aug 30. Fundam Clin Pharmacol. 2024. PMID: 37649138
Chemical composition and antibacterial effects of Etlingera elatior (Jack) R.M. Smith against Staphylococcus aureus efflux pumps.
de Sousa Ferreira F, de Araújo Neto JB, de Morais Oliveira-Tintino CD, de Araújo ACJ, Ribeiro-Filho J, Freitas PR, Araújo IM, Lima MA, de Azevedo FR, Tintino SR, Coutinho HDM, Navarro DMDAF. de Sousa Ferreira F, et al. Among authors: freitas pr. Chem Biol Interact. 2023 Dec 1;386:110751. doi: 10.1016/j.cbi.2023.110751. Epub 2023 Oct 10. Chem Biol Interact. 2023. PMID: 37821044
Assessment In vitro and In silico of the Activity of Thiadiazines as NorA Efflux Pump Inhibitors.
de Araújo ACJ, Freitas PR, Araújo IM, de Oliveira Borges JA, Gonçalves SA, Paulo CLR, Almeida RS, de Moraes Oliveira-Tintino CD, de Araújo-Neto JB, Dos Santos Nascimento IJ, de Araújo-Júnior JX, da Silva-Júnior EF, de Aquino TM, Junior FJBM, Marinho ES, Dos Santos HS, de Alencar Menezes IR, Tintino SR, Coutinho HDM, Braga MFBM. de Araújo ACJ, et al. Among authors: freitas pr. Curr Microbiol. 2024 Aug 24;81(10):325. doi: 10.1007/s00284-024-03836-0. Curr Microbiol. 2024. PMID: 39182011
Liposomal formulation with thiazolic compounds against bacterial efflux pumps.
de Almeida RS, Freitas PR, Justino de Araujo AC, Tintino SR, Ribeiro-Filho J, Miranda GM, Sigueira GM, Gonçalves SA, Carvalho DT, de Souza TB, Santos Folquitto LRD, Dias DF, Raposo A, Saraiva A, Han H, Coutinho HDM. de Almeida RS, et al. Among authors: freitas pr. Biomed Pharmacother. 2024 Nov;180:117600. doi: 10.1016/j.biopha.2024.117600. Epub 2024 Oct 30. Biomed Pharmacother. 2024. PMID: 39476763 Free article.
GC-MS Profile and Enhancement of Antibiotic Activity by the Essential Oil of Ocotea odorífera and Safrole: Inhibition of Staphylococcus aureus Efflux Pumps.
Almeida RS, Freitas PR, Araújo ACJ, Menezes IRA, Santos EL, Tintino SR, Moura TF, Filho JR, Ferreira VA, Silva ACA, Silva LE, Amaral WD, Deschamps C, Iriti M, Coutinho HDM. Almeida RS, et al. Among authors: freitas pr. Antibiotics (Basel). 2020 May 12;9(5):247. doi: 10.3390/antibiotics9050247. Antibiotics (Basel). 2020. PMID: 32408576 Free PMC article.
36 results