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Evaluating efflux pump inhibition in Staphylococcus aureus 1199B strain using thiadiazine-derived compounds: In vitro and in silico approaches.
Freitas PR, Araújo ACJ, Araújo IM, Almeida RS, Oliveira Borges JA, Lima CMG, Oliveira-Tintino CDM, Paulo CLR, Miranda GM, Araújo-Neto JB, Almeida-Bezerra JW, Nascimento IJDS, Araújo-Júnior JX, Silva-Júnior EFD, Aquino TM, Mendonca Junior FJB, Marinho ES, Santos HSD, Menezes IRA, Tintino SR, Coutinho HDM. Freitas PR, et al. Among authors: coutinho hdm. Biochimie. 2024 Dec 19:S0300-9084(24)00313-4. doi: 10.1016/j.biochi.2024.12.009. Online ahead of print. Biochimie. 2024. PMID: 39708974
Effect of hydroxyamines derived from lapachol and norlachol against Staphylococcus aureus strains carrying the NorA efflux pump.
Figueredo FG, Ramos ITL, Paz JA, Silva TMS, Câmara CA, de Morais Oliveira-Tintino CD, Tintino SR, de Farias PAM, Menezes IRA, Coutinho HDM, Fonteles MMF. Figueredo FG, et al. Among authors: coutinho hdm. Infect Genet Evol. 2020 Oct;84:104370. doi: 10.1016/j.meegid.2020.104370. Epub 2020 May 20. Infect Genet Evol. 2020. PMID: 32445918
Inhibition of the MepA efflux pump by limonene demonstrated by in vitro and in silico methods.
Freitas PR, de Araújo ACJ, Dos Santos Barbosa CR, Muniz DF, de Almeida RS, de Menezes IRA, da Costa JGM, Rodrigues FFG, Rocha JE, Pereira-Junior FN, Tintino SR, Coutinho HDM. Freitas PR, et al. Among authors: coutinho hdm. Folia Microbiol (Praha). 2022 Feb;67(1):15-20. doi: 10.1007/s12223-021-00909-6. Epub 2021 Aug 20. Folia Microbiol (Praha). 2022. PMID: 34417720
Antibacterial Activity of the Essential Oil of Piper tuberculatum Jacq. Fruits against Multidrug-Resistant Strains: Inhibition of Efflux Pumps and β-Lactamase.
da Silva LYS, Paulo CLR, Moura TF, Alves DS, Pessoa RT, Araújo IM, de Morais Oliveira-Tintino CD, Tintino SR, Nonato CFA, da Costa JGM, Ribeiro-Filho J, Coutinho HDM, Kowalska G, Mitura P, Bar M, Kowalski R, Menezes IRA. da Silva LYS, et al. Among authors: coutinho hdm. Plants (Basel). 2023 Jun 19;12(12):2377. doi: 10.3390/plants12122377. Plants (Basel). 2023. PMID: 37376002 Free PMC article.
Potentiating-antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi-drug resistant (MDR) strains.
de Araújo ACJ, Freitas PR, Araújo IM, Siqueira GM, de Oliveira Borges JA, Alves DS, Miranda GM, Dos Santos Nascimento IJ, de Araújo-Júnior JX, da Silva-Júnior EF, de Aquino TM, Junior FJBM, Marinho ES, Dos Santos HS, Tintino SR, Coutinho HDM. de Araújo ACJ, et al. Among authors: coutinho hdm. Fundam Clin Pharmacol. 2024 Feb;38(1):84-98. doi: 10.1111/fcp.12950. Epub 2023 Aug 30. Fundam Clin Pharmacol. 2024. PMID: 37649138
Chemical composition and antibacterial effects of Etlingera elatior (Jack) R.M. Smith against Staphylococcus aureus efflux pumps.
de Sousa Ferreira F, de Araújo Neto JB, de Morais Oliveira-Tintino CD, de Araújo ACJ, Ribeiro-Filho J, Freitas PR, Araújo IM, Lima MA, de Azevedo FR, Tintino SR, Coutinho HDM, Navarro DMDAF. de Sousa Ferreira F, et al. Among authors: coutinho hdm. Chem Biol Interact. 2023 Dec 1;386:110751. doi: 10.1016/j.cbi.2023.110751. Epub 2023 Oct 10. Chem Biol Interact. 2023. PMID: 37821044
Valencene, Nootkatone and Their Liposomal Nanoformulations as Potential Inhibitors of NorA, Tet(K), MsrA, and MepA Efflux Pumps in Staphylococcus aureus Strains.
Oliveira-Tintino CDM, Santana JEG, Alencar GG, Siqueira GM, Gonçalves SA, Tintino SR, Menezes IRA, Rodrigues JPV, Gonçalves VBP, Nicolete R, Ribeiro-Filho J, da Silva TG, Coutinho HDM. Oliveira-Tintino CDM, et al. Among authors: coutinho hdm. Pharmaceutics. 2023 Sep 28;15(10):2400. doi: 10.3390/pharmaceutics15102400. Pharmaceutics. 2023. PMID: 37896161 Free PMC article.
Assessment In vitro and In silico of the Activity of Thiadiazines as NorA Efflux Pump Inhibitors.
de Araújo ACJ, Freitas PR, Araújo IM, de Oliveira Borges JA, Gonçalves SA, Paulo CLR, Almeida RS, de Moraes Oliveira-Tintino CD, de Araújo-Neto JB, Dos Santos Nascimento IJ, de Araújo-Júnior JX, da Silva-Júnior EF, de Aquino TM, Junior FJBM, Marinho ES, Dos Santos HS, de Alencar Menezes IR, Tintino SR, Coutinho HDM, Braga MFBM. de Araújo ACJ, et al. Among authors: coutinho hdm. Curr Microbiol. 2024 Aug 24;81(10):325. doi: 10.1007/s00284-024-03836-0. Curr Microbiol. 2024. PMID: 39182011
In vitro and in silico effect of meldrum's acid-derived compounds on Staphylococcus aureus strains as NorA efflux pump inhibitors.
Araújo IM, Pereira RLS, de Araújo ACJ, Gonçalves SA, Tintino SR, de Morais Oliveira-Tintino CD, de Menezes IRA, Salamoni R, Begnini IM, Rebelo RA, da Silva LE, Domiciano CB, Coutinho HDM. Araújo IM, et al. Among authors: coutinho hdm. Biophys Chem. 2025 Jan;316:107344. doi: 10.1016/j.bpc.2024.107344. Epub 2024 Oct 18. Biophys Chem. 2025. PMID: 39442379
413 results