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Page 1
Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine.
Green RC, Goddard KAB, Jarvik GP, Amendola LM, Appelbaum PS, Berg JS, Bernhardt BA, Biesecker LG, Biswas S, Blout CL, Bowling KM, Brothers KB, Burke W, Caga-Anan CF, Chinnaiyan AM, Chung WK, Clayton EW, Cooper GM, East K, Evans JP, Fullerton SM, Garraway LA, Garrett JR, Gray SW, Henderson GE, Hindorff LA, Holm IA, Lewis MH, Hutter CM, Janne PA, Joffe S, Kaufman D, Knoppers BM, Koenig BA, Krantz ID, Manolio TA, McCullough L, McEwen J, McGuire A, Muzny D, Myers RM, Nickerson DA, Ou J, Parsons DW, Petersen GM, Plon SE, Rehm HL, Roberts JS, Robinson D, Salama JS, Scollon S, Sharp RR, Shirts B, Spinner NB, Tabor HK, Tarczy-Hornoch P, Veenstra DL, Wagle N, Weck K, Wilfond BS, Wilhelmsen K, Wolf SM, Wynn J, Yu JH; CSER Consortium. Green RC, et al. Among authors: chinnaiyan am. Am J Hum Genet. 2016 Jun 2;98(6):1051-1066. doi: 10.1016/j.ajhg.2016.04.011. Epub 2016 May 12. Am J Hum Genet. 2016. PMID: 27181682 Free PMC article.
Discovery of CBPD-409 as a Highly Potent, Selective, and Orally Efficacious CBP/p300 PROTAC Degrader for the Treatment of Advanced Prostate Cancer.
Chen Z, Wang M, Wu D, Zhao L, Metwally H, Jiang W, Wang Y, Bai L, McEachern D, Luo J, Wang M, Li Q, Matvekas A, Wen B, Sun D, Chinnaiyan AM, Wang S. Chen Z, et al. Among authors: chinnaiyan am. J Med Chem. 2024 Apr 11;67(7):5351-5372. doi: 10.1021/acs.jmedchem.3c01789. Epub 2024 Mar 26. J Med Chem. 2024. PMID: 38530938
Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance.
Yu J, Yan Y, Li S, Xu Y, Parolia A, Rizvi S, Wang W, Zhai Y, Xiao R, Li X, Liao P, Zhou J, Okla K, Lin H, Lin X, Grove S, Wei S, Vatan L, Hu J, Szumilo J, Kotarski J, Freeman ZT, Skala S, Wicha M, Cho KR, Chinnaiyan AM, Schon S, Wen F, Kryczek I, Wang S, Chen L, Zou W. Yu J, et al. Among authors: chinnaiyan am. Cell. 2024 Aug 22;187(17):4713-4732.e19. doi: 10.1016/j.cell.2024.06.012. Epub 2024 Jul 4. Cell. 2024. PMID: 38968937 Free article.
Discovery of the first selective and potent PROTAC degrader for the pseudokinase TRIB2.
Wen C, Gajjala PR, Liu Y, Chen B, Bal MS, Sutaria P, Yuanyuan Q, Zheng Y, Zhou Y, Zhang J, Huang W, Ren X, Wang Z, Ding K, Chinnaiyan AM, Zhou F. Wen C, et al. Among authors: chinnaiyan am. Eur J Med Chem. 2025 Jan 5;281:117016. doi: 10.1016/j.ejmech.2024.117016. Epub 2024 Nov 1. Eur J Med Chem. 2025. PMID: 39520729
Research autopsy programmes in oncology: shared experience from 14 centres across the world.
Geukens T, Maetens M, Hooper JE, Oesterreich S, Lee AV, Miller L, Atkinson JM, Rosenzweig M, Puhalla S, Thorne H, Devereux L, Bowtell D, Loi S, Bacon ER, Ihle K, Song M, Rodriguez-Rodriguez L, Welm AL, Gauchay L, Murali R, Chanda P, Karacay A, Naceur-Lombardelli C, Bridger H, Swanton C, Jamal-Hanjani M, Kollath L, True L, Morrissey C, Chambers M, Chinnaiyan AM, Wilson A, Mehra R, Reichert Z, Carey LA, Perou CM, Kelly E, Maeda D, Goto A, Kulka J, Székely B, Szasz AM, Tőkés AM, Van Den Bogaert W, Floris G, Desmedt C. Geukens T, et al. Among authors: chinnaiyan am. J Pathol. 2024 Jun;263(2):150-165. doi: 10.1002/path.6271. Epub 2024 Mar 29. J Pathol. 2024. PMID: 38551513 Free PMC article.
Discovery of ZLC491 as a Potent, Selective, and Orally Bioavailable CDK12/13 PROTAC Degrader.
Zhou L, Zhou K, Chang Y, Yang J, Fan B, Su Y, Li Z, Mannan R, Mahapatra S, Ding M, Zhou F, Huang W, Ren X, Xu J, Wang GX, Zhang J, Wang Z, Chinnaiyan AM, Ding K. Zhou L, et al. Among authors: chinnaiyan am. J Med Chem. 2024 Oct 24;67(20):18247-18264. doi: 10.1021/acs.jmedchem.4c01596. Epub 2024 Oct 10. J Med Chem. 2024. PMID: 39388374 Free PMC article.
Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader.
Liu L, Parolia A, Liu Y, Hou C, He T, Qiao Y, Eyunni S, Luo J, Li C, Wang Y, Zhou F, Huang W, Ren X, Wang Z, Chinnaiyan AM, Ding K. Liu L, et al. Among authors: chinnaiyan am. J Med Chem. 2024 May 9;67(9):6938-6951. doi: 10.1021/acs.jmedchem.3c01765. Epub 2024 Apr 30. J Med Chem. 2024. PMID: 38687638 Free PMC article.
647 results