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Page 1
Minimalist Natural ORPphilin Macarangin B Delineates OSBP Biological Function.
Jézéquel G, Grimanelli Z, Guimard C, Bigay J, Haddad J, Bignon J, Apel C, Steinmetz V, Askenatzis L, Levaïque H, Pradelli C, Pham VC, Huong DTM, Litaudon M, Gautier R, El Kalamouni C, Antonny B, Desrat S, Mesmin B, Roussi F. Jézéquel G, et al. Among authors: roussi f. J Med Chem. 2025 Jan 9;68(1):196-211. doi: 10.1021/acs.jmedchem.4c01705. Epub 2024 Dec 20. J Med Chem. 2025. PMID: 39704626
Structure-Based Design of a Lead Compound Derived from Natural Schweinfurthins with Antitumor Properties That Target Oxysterol-Binding Protein.
Jézéquel G, Rampal C, Guimard C, Kovacs D, Polidori J, Bigay J, Bignon J, Askenatzis L, Litaudon M, Pham VC, Huong DTM, Nguyen AL, Pruvost A, Virolle T, Mesmin B, Desrat S, Antonny B, Roussi F. Jézéquel G, et al. Among authors: roussi f. J Med Chem. 2023 Oct 26;66(20):14208-14220. doi: 10.1021/acs.jmedchem.3c01298. Epub 2023 Oct 5. J Med Chem. 2023. PMID: 37795600
Pro-apoptotic carboxamide analogues of natural fislatifolic acid targeting Mcl-1 and Bcl-2.
Gapil Tiamas S, Daressy F, Abou Samra A, Bignon J, Steinmetz V, Litaudon M, Fourneau C, Hoong Leong K, Ariffin A, Awang K, Desrat S, Roussi F. Gapil Tiamas S, et al. Among authors: roussi f. Bioorg Med Chem Lett. 2020 Apr 1;30(7):127003. doi: 10.1016/j.bmcl.2020.127003. Epub 2020 Feb 3. Bioorg Med Chem Lett. 2020. PMID: 32035700
Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor.
Péresse T, Kovacs D, Subra M, Bigay J, Tsai MC, Polidori J, Gautier R, Desrat S, Fleuriot L, Debayle D, Litaudon M, Pham VC, Bignon J, Antonny B, Roussi F, Mesmin B. Péresse T, et al. Among authors: roussi f. J Biol Chem. 2020 Mar 27;295(13):4277-4288. doi: 10.1074/jbc.RA119.012012. Epub 2020 Feb 19. J Biol Chem. 2020. PMID: 32075908 Free PMC article.
Pro-apoptotic meiogynin A derivatives that target Bcl-xL and Mcl-1.
Desrat S, Pujals A, Colas C, Dardenne J, Gény C, Favre L, Dumontet V, Iorga BI, Litaudon M, Raphaël M, Wiels J, Roussi F. Desrat S, et al. Among authors: roussi f. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5086-8. doi: 10.1016/j.bmcl.2014.09.004. Epub 2014 Sep 6. Bioorg Med Chem Lett. 2014. PMID: 25266781 Free article.
65 results