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Autistic identity: A systematic review of quantitative research.
Davies J, Cooper K, Killick E, Sam E, Healy M, Thompson G, Mandy W, Redmayne B, Crane L. Davies J, et al. Among authors: sam e. Autism Res. 2024 May;17(5):874-897. doi: 10.1002/aur.3105. Epub 2024 Feb 9. Autism Res. 2024. PMID: 38334318
Structure and catalytic activity of the SAM-utilizing ribozyme SAMURI.
Chen HA, Okuda T, Lenz AK, Scheitl CPM, Schindelin H, Höbartner C. Chen HA, et al. Nat Chem Biol. 2025 Jan 8. doi: 10.1038/s41589-024-01808-w. Online ahead of print. Nat Chem Biol. 2025. PMID: 39779902
Recently, we reported SAMURI as a site-specific alkyltransferase ribozyme using S-adenosylmethionine (SAM) or a stabilized analog to transfer a methyl or propargyl group to N(3) of an adenosine. ...
Recently, we reported SAMURI as a site-specific alkyltransferase ribozyme using S-adenosylmethionine (SAM) or a stabilized ana …
Comparison of Bacterial Intracellular and Secreted Proteins produced in Milk Versus Medium for Escherichia coli by Proteomic Analysis.
Sun Q, Li Y, Jiang H, Du Q, Wang J, Fan R, Han R, Yang Y. Sun Q, et al. J Dairy Sci. 2025 Jan 6:S0022-0302(24)01447-4. doi: 10.3168/jds.2024-25843. Online ahead of print. J Dairy Sci. 2025. PMID: 39778797 Free article.
Several bacterial intracellular and secretory proteins showed media-dependent changes, including hydrogenase-2 and s-adenosylmethionine synthase, which were only found in the LB medium. In contrast, DNA polymerase III subunit alpha and cold shock-like protein CspD ( …
Several bacterial intracellular and secretory proteins showed media-dependent changes, including hydrogenase-2 and s-adenosylmethi …
The Simultaneous Treatment of PC-3 Cells with the DNA-Demethylating Agent Decitabine and S-Adenosylmethionine Leads to Synergistic Anticancer Effects.
Schmidt T, Sticht C. Schmidt T, et al. Genes (Basel). 2024 Dec 20;15(12):1634. doi: 10.3390/genes15121634. Genes (Basel). 2024. PMID: 39766901 Free PMC article.
Therefore, we aimed to investigate the effect of a combination of S-adenosylmethionine (SAM) and the demethylating agent decitabine on prostate cancer cells. ...
Therefore, we aimed to investigate the effect of a combination of S-adenosylmethionine (SAM) and the demethylating agent decit …
MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial.
Gounder M, Johnson M, Heist RS, Shapiro GI, Postel-Vinay S, Wilson FH, Garralda E, Wulf G, Almon C, Nabhan S, Aguado-Fraile E, He P, Romagnoli M, Hossain M, Narayanaswamy R, Sadou-Dubourgnoux A, Cooper M, Askoxylakis V, Burris HA, Tabernero J. Gounder M, et al. Nat Commun. 2025 Jan 6;16(1):423. doi: 10.1038/s41467-024-55316-5. Nat Commun. 2025. PMID: 39762248 Free PMC article. Clinical Trial.
Homozygous MTAP deletion occurs in ~15% of cancers, making them vulnerable to decreases in the concentration of S-adenosylmethionine (SAM). AG-270/S095033 is an oral, potent, reversible inhibitor of methionine adenosyltransferase 2 A (MAT2A), the enzyme primarily re …
Homozygous MTAP deletion occurs in ~15% of cancers, making them vulnerable to decreases in the concentration of S-adenosylmethioni …
High quality Bathyarchaeia MAGs from lignocellulose-impacted environments elucidate metabolism and evolutionary mechanisms.
Nesbø CL, Kublanov I, Yang M, Sharan AA, Meyer T, Edwards EA. Nesbø CL, et al. ISME Commun. 2024 Dec 10;4(1):ycae156. doi: 10.1093/ismeco/ycae156. eCollection 2024 Jan. ISME Commun. 2024. PMID: 39759836 Free PMC article.
All the Bathy-6 MAGs had numerous membrane-associated pyrroloquinoline quinone-domain proteins that we suggest are involved in lignin modification or degradation, together with Radical-S-adenosylmethionine (SAM) and Rieske domain proteins, and AA2, AA3, and AA6-fami …
All the Bathy-6 MAGs had numerous membrane-associated pyrroloquinoline quinone-domain proteins that we suggest are involved in lignin modifi …
NNMT suppresses H3K9me3 to facilitate malignant progression and drug resistance in gastric cancer.
Wang B, Wu T. Wang B, et al. Arab J Gastroenterol. 2025 Jan 4:S1687-1979(24)00132-1. doi: 10.1016/j.ajg.2024.12.004. Online ahead of print. Arab J Gastroenterol. 2025. PMID: 39757078
We applied the Transwell assay to measure cell migration and invasion ability. The content of S-adenosylmethionine (SAM) and S-adenosyl-L-homocysteine (SAH) in cells was measured by enzyme-linked immunosorbent assay (ELISA). ...
We applied the Transwell assay to measure cell migration and invasion ability. The content of S-adenosylmethionine (SAM) and S …
Arsenic Exposure Triggers Nonalcoholic Fatty Liver Disease through Repressing S-Adenosylmethionine-Dependent Histone Methylation in Rats.
Lu L, Hua W, Li F, Che Z, Tian M, Lu YY, Chi Q, Zhang J, Huang Q. Lu L, et al. Environ Sci Technol. 2025 Jan 14;59(1):268-278. doi: 10.1021/acs.est.4c10417. Epub 2025 Jan 2. Environ Sci Technol. 2025. PMID: 39746780
In addition, it was found that inorganic arsenite (iAs(III)) was methylated to DMA, and the S-adenosylmethionine (SAM) level was decreased, which would contribute to the repression of H3K9me1/2 in rat liver after exposure. ...
In addition, it was found that inorganic arsenite (iAs(III)) was methylated to DMA, and the S-adenosylmethionine (SAM) level w …
SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signaling pathway to facilitate viral replication.
Zhou S, Hui X, Wang W, Zhao C, Jin M, Qin Y, Chen M. Zhou S, et al. Emerg Microbes Infect. 2025 Jan 2:2447620. doi: 10.1080/22221751.2024.2447620. Online ahead of print. Emerg Microbes Infect. 2025. PMID: 39745173 Free article.
Specifically, the viral non-structural protein nsp14 upregulates the expression of S-adenosylmethionine synthase MAT2A in an mTORC1-dependent manner. This mTORC1-MAT2A axis subsequently stimulates the synthesis of S-adenosylmethionine (SAM). ...
Specifically, the viral non-structural protein nsp14 upregulates the expression of S-adenosylmethionine synthase MAT2A in an m …
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