Feng F - Search Results

1

A Self-Assembled Nano-Molecular Glue (Nano-mGlu) Enables GSH/H₂O₂-Triggered Targeted Protein Degradation in Cancer Therapy.

Sun J, Gu M, Peng L, Guo J, Chen P, Wen Y, Feng F, Chen X, Liu T, Chen Y, Lu X, Gao L, Yao SQ, Yuan P. Sun J, et al. Among authors: feng f. J Am Chem Soc. 2025 Jan 8;147(1):372-383. doi: 10.1021/jacs.4c11003. Epub 2024 Dec 20. J Am Chem Soc. 2025. PMID: 39703105

2

Design, Synthesis, and Evaluation of (R)-8-((Tetrahydrofuran-2-yl)methyl)pyrido[2,3-d]pyrimidin-7-ones as Novel Selective ACK1 Inhibitors to Combat Acquired Resistance to the Third-Generation EGFR Inhibitor.

Li Q, Zhang T, Song P, Tong L, Feng F, Guo J, Zhou Y, Xie H, Lu X. Li Q, et al. Among authors: feng f. J Med Chem. 2023 May 25;66(10):6905-6921. doi: 10.1021/acs.jmedchem.3c00319. Epub 2023 May 3. J Med Chem. 2023. PMID: 37134203

3

Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1-Amplified Breast Cancer.

Wang C, Fang Y, Zhou Z, Liu Z, Feng F, Wan X, Li Y, Liu S, Ding J, Zhang ZM, Xie H, Lu X. Wang C, et al. Among authors: feng f. J Med Chem. 2024 Sep 12;67(17):15816-15836. doi: 10.1021/acs.jmedchem.4c01458. Epub 2024 Aug 20. J Med Chem. 2024. PMID: 39163619

4

Design, Synthesis, and Biological Evaluation of Novel Diaminopyrimidine Macrocycles as Fourth Generation Reversible EGFR Inhibitors That Overcome Clinical Resistance to Osimertinib Mediated by C797S Mutation.

Hu S, Tong L, Qin Q, Wen J, Li Y, Feng F, Wu K, Zhou Y, Shang J, Wang J, Liu J, Xie H, Lu X. Hu S, et al. Among authors: feng f. J Med Chem. 2024 Nov 28;67(22):20531-20558. doi: 10.1021/acs.jmedchem.4c01975. Epub 2024 Nov 13. J Med Chem. 2024. PMID: 39536262

5

LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo.

Liu Y, Lai M, Li S, Wang Y, Feng F, Zhang T, Tong L, Zhang M, Chen H, Chen Y, Song P, Li Y, Bai G, Ning Y, Tang H, Fang Y, Chen Y, Lu X, Geng M, Ding K, Yu K, Xie H, Ding J. Liu Y, et al. Among authors: feng f. Cancer Sci. 2022 Feb;113(2):709-720. doi: 10.1111/cas.15229. Epub 2021 Dec 16. Cancer Sci. 2022. PMID: 34855271 Free PMC article.

6

Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo.

Lai M, Zhang T, Chen H, Song P, Tong L, Chen J, Liu Y, Ning Y, Feng F, Li Y, Tang H, Chen Y, Fang Y, Lu X, Geng M, Ding K, Yu K, Ding J, Xie H. Lai M, et al. Among authors: feng f. J Cancer. 2023 Jan 1;14(1):152-162. doi: 10.7150/jca.77788. eCollection 2023. J Cancer. 2023. PMID: 36605493 Free PMC article.

7

Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R.

Liu YQ, Wang YN, Lu XY, Tong LJ, Li Y, Zhang T, Xun QJ, Feng F, Chen YZ, Su Y, Shen YY, Chen Y, Geng MY, Ding K, Li YL, Xie H, Ding J. Liu YQ, et al. Among authors: feng f. Acta Pharmacol Sin. 2018 Nov;39(11):1768-1776. doi: 10.1038/s41401-018-0056-0. Epub 2018 Jul 3. Acta Pharmacol Sin. 2018. PMID: 29968849 Free PMC article.

8

Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study.

Sun Y, Tang H, Wang X, Feng F, Fan T, Zhao D, Xiong B, Xie H, Liu T. Sun Y, et al. Among authors: feng f. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1411-1425. doi: 10.1080/14756366.2022.2076674. J Enzyme Inhib Med Chem. 2022. PMID: 35587686 Free PMC article.

9

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance.

Zhang T, Qu R, Chan S, Lai M, Tong L, Feng F, Chen H, Song T, Song P, Bai G, Liu Y, Wang Y, Li Y, Su Y, Shen Y, Sun Y, Chen Y, Geng M, Ding K, Ding J, Xie H. Zhang T, et al. Among authors: feng f. Mol Cancer. 2020 May 13;19(1):90. doi: 10.1186/s12943-020-01202-9. Mol Cancer. 2020. PMID: 32404161 Free PMC article.

10

Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma.

Liu Y, Zhan Z, Kang Z, Li M, Lv Y, Li S, Tong L, Feng F, Li Y, Zhang M, Xue Y, Chen Y, Zhang T, Song P, Su Y, Shen Y, Sun Y, Yang X, Chen Y, Yao S, Yang H, Wang C, Geng M, Li W, Duan W, Xie H, Ding J. Liu Y, et al. Among authors: feng f. Acta Pharm Sin B. 2023 Dec;13(12):4748-4764. doi: 10.1016/j.apsb.2023.09.009. Epub 2023 Sep 22. Acta Pharm Sin B. 2023. PMID: 38045044 Free PMC article.

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