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Page 1
Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells.
Zhang Z, Langenbach M, Sagar S, Fetsch V, Stritzker J, Severa E, Meng K, Winkler F, Rana N, Zoldan K, Godbole I, Solis S, Weber JS, Rafei-Shamsabadi D, Lehr S, Diehl R, Venhoff AC, Voll RE, Buettner N, Neumann-Haefelin C, Boettler T, Hofmann M, Boerries M, Meiss F, Zeiser R, Thimme R, Herati RS, Bengsch B. Zhang Z, et al. Among authors: neumann haefelin c. Nat Immunol. 2025 Jan;26(1):92-104. doi: 10.1038/s41590-024-02027-0. Epub 2024 Dec 19. Nat Immunol. 2025. PMID: 39702858
Attenuated effector T cells are linked to control of chronic HBV infection.
Heim K, Sagar, Sogukpinar Ö, Llewellyn-Lacey S, Price DA, Emmerich F, Kraft ARM, Cornberg M, Kielbassa S, Knolle P, Wohlleber D, Bengsch B, Boettler T, Neumann-Haefelin C, Thimme R, Hofmann M. Heim K, et al. Among authors: neumann haefelin c. Nat Immunol. 2024 Sep;25(9):1650-1662. doi: 10.1038/s41590-024-01928-4. Epub 2024 Aug 28. Nat Immunol. 2024. PMID: 39198634 Free PMC article.
Adaptive immune responses in hepatitis C virus infection.
Neumann-Haefelin C, Thimme R. Neumann-Haefelin C, et al. Curr Top Microbiol Immunol. 2013;369:243-62. doi: 10.1007/978-3-642-27340-7_10. Curr Top Microbiol Immunol. 2013. PMID: 23463204 Review.
Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection.
Hensel N, Gu Z, Sagar, Wieland D, Jechow K, Kemming J, Llewellyn-Lacey S, Gostick E, Sogukpinar O, Emmerich F, Price DA, Bengsch B, Boettler T, Neumann-Haefelin C, Eils R, Conrad C, Bartenschlager R, Grün D, Ishaque N, Thimme R, Hofmann M. Hensel N, et al. Nat Immunol. 2021 Feb;22(2):229-239. doi: 10.1038/s41590-020-00817-w. Epub 2021 Jan 4. Nat Immunol. 2021. PMID: 33398179
Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine.
Oberhardt V, Luxenburger H, Kemming J, Schulien I, Ciminski K, Giese S, Csernalabics B, Lang-Meli J, Janowska I, Staniek J, Wild K, Basho K, Marinescu MS, Fuchs J, Topfstedt F, Janda A, Sogukpinar O, Hilger H, Stete K, Emmerich F, Bengsch B, Waller CF, Rieg S, Sagar, Boettler T, Zoldan K, Kochs G, Schwemmle M, Rizzi M, Thimme R, Neumann-Haefelin C, Hofmann M. Oberhardt V, et al. Nature. 2021 Sep;597(7875):268-273. doi: 10.1038/s41586-021-03841-4. Epub 2021 Jul 28. Nature. 2021. PMID: 34320609 Free PMC article.
Immunopathology caused by impaired CD8+ T-cell responses.
Aichele P, Neumann-Haefelin C, Ehl S, Thimme R, Cathomen T, Boerries M, Hofmann M. Aichele P, et al. Eur J Immunol. 2022 Sep;52(9):1390-1395. doi: 10.1002/eji.202149528. Epub 2022 Feb 11. Eur J Immunol. 2022. PMID: 35099807 Free article. Review.
Exhaustion of CD39-Expressing CD8+ T Cells in Crohn's Disease Is Linked to Clinical Outcome.
Globig AM, Mayer LS, Heeg M, Andrieux G, Ku M, Otto-Mora P, Hipp AV, Zoldan K, Pattekar A, Rana N, Schell C, Boerries M, Hofmann M, Neumann-Haefelin C, Kuellmer A, Schmidt A, Boettler T, Tomov V, Thimme R, Hasselblatt P, Bengsch B. Globig AM, et al. Gastroenterology. 2022 Oct;163(4):965-981.e31. doi: 10.1053/j.gastro.2022.06.045. Epub 2022 Jun 20. Gastroenterology. 2022. PMID: 35738329
Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8+ T cells.
Winkler F, Hipp AV, Ramirez C, Martin B, Villa M, Neuwirt E, Gorka O, Aerssens J, Johansson SE, Rana N, Llewellyn-Lacey S, Price DA, Panning M, Groß O, Pearce EL, Hermann CM, Schumann K, Hannibal L, Neumann-Haefelin C, Boettler T, Knolle P, Hofmann M, Wohlleber D, Thimme R, Bengsch B. Winkler F, et al. Gut. 2023 Oct;72(10):1971-1984. doi: 10.1136/gutjnl-2022-328734. Epub 2023 Aug 4. Gut. 2023. PMID: 37541771 Free PMC article.
164 results