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Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys.
Wu M, Lin P, Li L, Chen D, Yang X, Xu L, Zhou B, Wang C, Zhang Y, Luo C, Ye C. Wu M, et al. FASEB J. 2019 Jun;33(6):6948-6956. doi: 10.1096/fj.201802585RR. Epub 2019 Mar 6. FASEB J. 2019. PMID: 30840839
Finally, we conclude that ADMA has an antifibrotic effect in obstructed kidneys, and future application of type I PRMT inhibitor should be done cautiously for patients with CKD.-Wu, M., Lin, P., Li, L., Chen, D., Yang, X., Xu, L., Zhou, B., Wang, C., Zhang, Y., Luo, …
Finally, we conclude that ADMA has an antifibrotic effect in obstructed kidneys, and future application of type I PRMT inhibitor should be d …
Renal asymmetric dimethylarginine inhibits fibrosis.
Wu M, Yuan M, Wang Y, Tan B, Huang D, Wang C, Zou Y, Ye C. Wu M, et al. FEBS Open Bio. 2020 Oct;10(10):2003-2009. doi: 10.1002/2211-5463.12949. Epub 2020 Aug 30. FEBS Open Bio. 2020. PMID: 32794631 Free PMC article.
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