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Page 1
Circulating cytokine associations with clinical outcomes in melanoma patients treated with combination nivolumab plus ipilimumab.
Chen J, Tarantino G, Severgnini M, Baginska J, Giobbie-Hurder A, Weirather JL, Manos M, Russell JD, Pfaff KL, Rodig SJ, Huang AY, Brennick R, Nazzaro M, Hathaway E, Holovatska M, Manuszak C, Ranasinghe S, Liu D, Hodi FS. Chen J, et al. Among authors: huang ay. Oncoimmunology. 2025 Dec;14(1):2432723. doi: 10.1080/2162402X.2024.2432723. Epub 2024 Dec 19. Oncoimmunology. 2025. PMID: 39699928 Free PMC article.
Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanoma.
Tarantino G, Ricker CA, Wang A, Ge W, Aprati TJ, Huang AY, Madha S, Chen J, Shi Y, Glettig M, Feng CH, Frederick DT, Freeman S, Holovatska MM, Manos MP, Zimmer L, Rösch A, Zaremba A, Livingstone E, Jameson JC, Saghafian S, Lee A, Zhao K, Morris LGT, Reardon B, Park J, Elmarakeby HA, Schilling B, Giobbie-Hurder A, Vokes NI, Buchbinder EI, Flaherty KT, Haq R, Wu CJ, Boland GM, Hodi FS, Van Allen EM, Schadendorf D, Liu D. Tarantino G, et al. Among authors: huang ay. Sci Adv. 2024 Nov 29;10(48):eadp4670. doi: 10.1126/sciadv.adp4670. Epub 2024 Nov 27. Sci Adv. 2024. PMID: 39602539 Free PMC article.
Stratified analysis identifies HIF-2α as a therapeutic target for highly immune-infiltrated melanomas.
Huang AY, Burke KP, Porter R, Meiger L, Fatouros P, Yang J, Robitschek E, Vokes N, Ricker C, Rosado V, Tarantino G, Chen J, Aprati TJ, Glettig MC, He Y, Wang C, Fu D, Ho LL, Galani K, Freeman GJ, Buchbinder EI, Stephen Hodi F, Kellis M, Boland GM, Sharpe AH, Liu D. Huang AY, et al. bioRxiv [Preprint]. 2024 Oct 30:2024.10.29.620300. doi: 10.1101/2024.10.29.620300. bioRxiv. 2024. PMID: 39554029 Free PMC article. Preprint.
Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity.
Georgiev P, Han S, Huang AY, Nguyen TH, Drijvers JM, Creasey H, Pereira JA, Yao CH, Park JS, Conway TS, Fung ME, Liang D, Peluso M, Joshi S, Rowe JH, Miller BC, Freeman GJ, Sharpe AH, Haigis MC, Ringel AE. Georgiev P, et al. Among authors: huang ay. Cancer Immunol Res. 2024 Nov 4;12(11):1525-1541. doi: 10.1158/2326-6066.CIR-24-0463. Cancer Immunol Res. 2024. PMID: 39186561 Free PMC article.
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control.
Weiss SA, Huang AY, Fung ME, Martinez D, Chen ACY, LaSalle TJ, Miller BC, Scharer CD, Hegde M, Nguyen TH, Rowe JH, Osborn JF, Patterson DG, Sifnugel N, Mei-An Nolan C, Davidson RA, Schwartz MA, Bally APR, Neeld DK, LaFleur MW, Boss JM, Doench JG, Nicholas Haining W, Sharpe AH, Sen DR. Weiss SA, et al. Among authors: huang ay. Nat Immunol. 2024 Oct;25(10):1871-1883. doi: 10.1038/s41590-024-01961-3. Epub 2024 Sep 17. Nat Immunol. 2024. PMID: 39289557
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system.
LaFleur MW, Lemmen AM, Streeter ISL, Nguyen TH, Milling LE, Derosia NM, Hoffman ZM, Gillis JE, Tjokrosurjo Q, Markson SC, Huang AY, Anekal PV, Montero Llopis P, Haining WN, Doench JG, Sharpe AH. LaFleur MW, et al. Among authors: huang ay. Nat Immunol. 2024 Jan;25(1):178-188. doi: 10.1038/s41590-023-01689-6. Epub 2023 Nov 27. Nat Immunol. 2024. PMID: 38012416 Free PMC article.
Basic Science and Pathogenesis.
Huang AY, Zhou Z, Talukdar M, Miller MB, Chhouk B, Enyenihi L, Rosen I, Stronge E, Zhao B, Kim D, Choi J, Khoshkhoo S, Kim J, Ganz J, Travaglini KJ, Gabitto MI, Hodge RD, Kaplan ES, Lein ES, De Jager PL, Bennett DA, Lee EA, Walsh CA. Huang AY, et al. Alzheimers Dement. 2024 Dec;20 Suppl 1:e084786. doi: 10.1002/alz.084786. Alzheimers Dement. 2024. PMID: 39751389
Basic Science and Pathogenesis.
Jin B, Naik S, Kirkham SL, Qian X, Zhou Z, Oakley D, Frosch MP, Hyman BTT, Huang AY, Miller MB. Jin B, et al. Among authors: huang ay. Alzheimers Dement. 2024 Dec;20 Suppl 1:e093457. doi: 10.1002/alz.093457. Alzheimers Dement. 2024. PMID: 39751333
Basic Science and Pathogenesis.
Miller MB, Ma C, Dong G, Naik S, McDonough G, Mao S, McKee AC, Huang AY, Lee EA, Walsh CA. Miller MB, et al. Among authors: huang ay. Alzheimers Dement. 2024 Dec;20 Suppl 1:e091891. doi: 10.1002/alz.091891. Alzheimers Dement. 2024. PMID: 39751207
254 results