Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer.
Pan Y, Lu F, Fei Q, Yu X, Xiong P, Yu X, Dang Y, Hou Z, Lin W, Lin X, Zhang Z, Pan M, Huang H.
Pan Y, et al. Among authors: pan m.
J Hematol Oncol. 2019 Nov 27;12(1):124. doi: 10.1186/s13045-019-0822-6.
J Hematol Oncol. 2019.
PMID: 31771616
Free PMC article.
METHODS: Using immunohistochemistry, we examined tumor-infiltrating CD68(+) pan-macrophages (CD68(+) M) and CD163(+) M2 macrophages (CD163(+) M2) and tumor expression of CD47 and PD-L1 proteins in 106 cases of PDAC. ...CD47(high)/CD68(+) M(high) and CD47(high …
METHODS: Using immunohistochemistry, we examined tumor-infiltrating CD68(+) pan-macrophages (CD68(+) M) and CD163(+) M2 macrop …