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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing.
Qu Q, Chen Y, Wang Y, Wang W, Long S, Yang HY, Wu J, Li M, Tian X, Wei X, Liu YH, Xu S, Xiong J, Yang C, Wu Z, Huang X, Xie C, Wu Y, Xu Z, Zhang C, Zhang B, Feng JW, Chen J, Feng Y, Fang H, Lin L, Xie ZK, Sun B, Tian H, Yu Y, Piao HL, Xie XS, Deng X, Zhang CS, Lin SC. Qu Q, et al. Among authors: piao hl. Nature. 2024 Dec 18. doi: 10.1038/s41586-024-08348-2. Online ahead of print. Nature. 2024. PMID: 39695235
Lithocholic acid phenocopies anti-ageing effects of calorie restriction.
Qu Q, Chen Y, Wang Y, Long S, Wang W, Yang HY, Li M, Tian X, Wei X, Liu YH, Xu S, Zhang C, Zhu M, Lam SM, Wu J, Yun C, Chen J, Xue S, Zhang B, Zheng ZZ, Piao HL, Jiang C, Guo H, Shui G, Deng X, Zhang CS, Lin SC. Qu Q, et al. Among authors: piao hl. Nature. 2024 Dec 18. doi: 10.1038/s41586-024-08329-5. Online ahead of print. Nature. 2024. PMID: 39695227
AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension.
Li M, Wang Y, Wei X, Cai WF, Liu YH, Wu J, Chen Y, Xiong J, Cui LF, Zhu M, Zhang C, Lin L, Yu Y, Piao HL, Lin SC, Zhang CS. Li M, et al. Among authors: piao hl. Cell Res. 2024 Nov;34(11):806-809. doi: 10.1038/s41422-024-01021-3. Epub 2024 Sep 19. Cell Res. 2024. PMID: 39300254 Free PMC article. No abstract available.
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.
Li M, Wang Y, Wei X, Cai WF, Wu J, Zhu M, Wang Y, Liu YH, Xiong J, Qu Q, Chen Y, Tian X, Yao L, Xie R, Li X, Chen S, Huang X, Zhang C, Xie C, Wu Y, Xu Z, Zhang B, Jiang B, Wang ZC, Li Q, Li G, Lin SY, Yu L, Piao HL, Deng X, Han J, Zhang CS, Lin SC. Li M, et al. Among authors: piao hl. Cell Res. 2024 Oct;34(10):683-706. doi: 10.1038/s41422-024-00985-6. Epub 2024 Jun 19. Cell Res. 2024. PMID: 38898113 Free PMC article.
116 results