White A - Search Results

1

The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron.

Sloop KW, Cox AL, Wainscott DB, White A, Droz BA, Stutsman C, Showalter AD, Suter TM, Dunbar JD, Snider BM, O'Farrell LS, Hewitt N, Ruble JC, Padgett LR, Woerly EM, Peterson JA, Coskun T, Liu Z, Coutant DE, Ai M, Emmerson PJ, Sangwung P, Willard FS. Sloop KW, et al. Among authors: white a. Sci Transl Med. 2024 Dec 18;16(778):eadp5765. doi: 10.1126/scitranslmed.adp5765. Epub 2024 Dec 18. Sci Transl Med. 2024. PMID: 39693407

2

Use of Backbone Modification To Enlarge the Spatiotemporal Diversity of Parathyroid Hormone Receptor-1 Signaling via Biased Agonism.

Liu S, Jean-Alphonse FG, White AD, Wootten D, Sexton PM, Gardella TJ, Vilardaga JP, Gellman SH. Liu S, et al. J Am Chem Soc. 2019 Sep 18;141(37):14486-14490. doi: 10.1021/jacs.9b04179. Epub 2019 Sep 9. J Am Chem Soc. 2019. PMID: 31496241 Free PMC article.

3

Precise druggability of the PTH type 1 receptor.

Sutkeviciute I, Lee JY, White AD, Maria CS, Peña KA, Savransky S, Doruker P, Li H, Lei S, Kaynak B, Tu C, Clark LJ, Sanker S, Gardella TJ, Chang W, Bahar I, Vilardaga JP. Sutkeviciute I, et al. Among authors: white ad. Nat Chem Biol. 2022 Mar;18(3):272-280. doi: 10.1038/s41589-021-00929-w. Epub 2021 Dec 23. Nat Chem Biol. 2022. PMID: 34949836 Free PMC article.

4

Molecular Mechanisms of PTH/PTHrP Class B GPCR Signaling and Pharmacological Implications.

Vilardaga JP, Clark LJ, White AD, Sutkeviciute I, Lee JY, Bahar I. Vilardaga JP, et al. Endocr Rev. 2023 May 8;44(3):474-491. doi: 10.1210/endrev/bnac032. Endocr Rev. 2023. PMID: 36503956 Free PMC article.

5

G_q/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR.

White AD, Jean-Alphonse FG, Fang F, Peña KA, Liu S, König GM, Inoue A, Aslanoglou D, Gellman SH, Kostenis E, Xiao K, Vilardaga JP. White AD, et al. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7455-7460. doi: 10.1073/pnas.1918158117. Epub 2020 Mar 17. Proc Natl Acad Sci U S A. 2020. PMID: 32184323 Free PMC article.

6

Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its N-terminal fragment 1 to 36.

Peña KA, White AD, Savransky S, Castillo IP, Jean-Alphonse FG, Gardella TJ, Sutkeviciute I, Vilardaga JP. Peña KA, et al. Among authors: white ad. J Biol Chem. 2022 Sep;298(9):102332. doi: 10.1016/j.jbc.2022.102332. Epub 2022 Aug 4. J Biol Chem. 2022. PMID: 35933010 Free PMC article.

7

Deciphering the role of glycosaminoglycans in GPCR signaling.

Savransky S, White AD, Vilardaga JP. Savransky S, et al. Cell Signal. 2024 Jun;118:111149. doi: 10.1016/j.cellsig.2024.111149. Epub 2024 Mar 22. Cell Signal. 2024. PMID: 38522808 Free article. Review.

8

PTH/PTHrP Receptor Signaling, Allostery, and Structures.

Sutkeviciute I, Clark LJ, White AD, Gardella TJ, Vilardaga JP. Sutkeviciute I, et al. Trends Endocrinol Metab. 2019 Nov;30(11):860-874. doi: 10.1016/j.tem.2019.07.011. Trends Endocrinol Metab. 2019. PMID: 31699241 Free PMC article. Review.

9

Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation.

White AD, Peña KA, Clark LJ, Maria CS, Liu S, Jean-Alphonse FG, Lee JY, Lei S, Cheng Z, Tu CL, Fang F, Szeto N, Gardella TJ, Xiao K, Gellman SH, Bahar I, Sutkeviciute I, Chang W, Vilardaga JP. White AD, et al. Sci Signal. 2021 Oct 5;14(703):eabc5944. doi: 10.1126/scisignal.abc5944. Epub 2021 Oct 5. Sci Signal. 2021. PMID: 34609896 Free PMC article.

10

Hair Straightener Use in Relation to Prevalent and Incident Fibroids in the Sister Study with a Focus on Black Women.

Ogunsina K, O'Brien KM, White AJ, Chang CJ, Gaston SA, Jackson CL, Sandler DP. Ogunsina K, et al. Among authors: white aj. Environ Health Perspect. 2025 Jan;133(1):17004. doi: 10.1289/EHP14493. Epub 2025 Jan 14. Environ Health Perspect. 2025. PMID: 39808082

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