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Low-inflammatory lipid nanoparticle-based mRNA vaccine elicits protective immunity against H5N1 high-pathogenicity avian influenza virus with reduced adverse reactions.
Kawai A, Shimizu T, Tanaka H, Shichinohe S, Anindita J, Hirose M, Kawahara E, Senpuku K, Shimooka M, Quynh Mai LT, Suzuki R, Nogimori T, Yamamoto T, Hirai T, Kato T, Watanabe T, Akita H, Yoshioka Y. Kawai A, et al. Among authors: kato t. Mol Ther. 2024 Dec 17:S1525-0016(24)00831-1. doi: 10.1016/j.ymthe.2024.12.032. Online ahead of print. Mol Ther. 2024. PMID: 39690742 Free article.
Lipid Nanoparticle with 1,2-Di-O-octadecenyl-3-trimethylammonium-propane as a Component Lipid Confers Potent Responses of Th1 Cells and Antibody against Vaccine Antigen.
Kawai A, Noda M, Hirata H, Munakata L, Matsuda T, Omata D, Takemura N, Onoe S, Hirose M, Kato T, Saitoh T, Hirai T, Suzuki R, Yoshioka Y. Kawai A, et al. Among authors: kato t. ACS Nano. 2024 Jul 2;18(26):16589-16609. doi: 10.1021/acsnano.4c00278. Epub 2024 Jun 17. ACS Nano. 2024. PMID: 38885198 Free PMC article.
An Ionizable Lipid Material with a Vitamin E Scaffold as an mRNA Vaccine Platform for Efficient Cytotoxic T Cell Responses.
Oyama R, Ishigame H, Tanaka H, Tateshita N, Itazawa M, Imai R, Nishiumi N, Kishikawa JI, Kato T, Anindita J, Nishikawa Y, Maeki M, Tokeshi M, Tange K, Nakai Y, Sakurai Y, Okada T, Akita H. Oyama R, et al. Among authors: kato t. ACS Nano. 2023 Oct 10;17(19):18758-18774. doi: 10.1021/acsnano.3c02251. Epub 2023 Sep 26. ACS Nano. 2023. PMID: 37814788 Free PMC article.
Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP.
Imaizumi Y, Takanuki K, Miyake T, Takemoto M, Hirata K, Hirose M, Oi R, Kobayashi T, Miyoshi K, Aruga R, Yokoyama T, Katagiri S, Matsuura H, Iwasaki K, Kato T, Kaneko MK, Kato Y, Tajiri M, Akashi S, Nureki O, Hizukuri Y, Akiyama Y, Nogi T. Imaizumi Y, et al. Among authors: kato t, kato y. Sci Adv. 2022 Aug 26;8(34):eabp9011. doi: 10.1126/sciadv.abp9011. Epub 2022 Aug 24. Sci Adv. 2022. PMID: 36001659 Free PMC article.
Structure of MotA, a flagellar stator protein, from hyperthermophile.
Nishikino T, Takekawa N, Tran DP, Kishikawa JI, Hirose M, Onoe S, Kojima S, Homma M, Kitao A, Kato T, Imada K. Nishikino T, et al. Among authors: kato t. Biochem Biophys Res Commun. 2022 Nov 26;631:78-85. doi: 10.1016/j.bbrc.2022.09.072. Epub 2022 Sep 21. Biochem Biophys Res Commun. 2022. PMID: 36179499
An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models.
Urano E, Itoh Y, Suzuki T, Sasaki T, Kishikawa JI, Akamatsu K, Higuchi Y, Sakai Y, Okamura T, Mitoma S, Sugihara F, Takada A, Kimura M, Nakao S, Hirose M, Sasaki T, Koketsu R, Tsuji S, Yanagida S, Shioda T, Hara E, Matoba S, Matsuura Y, Kanda Y, Arase H, Okada M, Takagi J, Kato T, Hoshino A, Yasutomi Y, Saito A, Okamoto T. Urano E, et al. Among authors: kato t. Sci Transl Med. 2023 Aug 30;15(711):eadi2623. doi: 10.1126/scitranslmed.adi2623. Epub 2023 Aug 30. Sci Transl Med. 2023. PMID: 37647387
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