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Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.
Mahindroo N, Huang CF, Peng YH, Wang CC, Liao CC, Lien TW, Chittimalla SK, Huang WJ, Chai CH, Prakash E, Chen CP, Hsu TA, Peng CH, Lu IL, Lee LH, Chang YW, Chen WC, Chou YC, Chen CT, Goparaju CM, Chen YS, Lan SJ, Yu MC, Chen X, Chao YS, Wu SY, Hsieh HP. Mahindroo N, et al. Among authors: hsieh hp. J Med Chem. 2005 Dec 29;48(26):8194-208. doi: 10.1021/jm0506930. J Med Chem. 2005. PMID: 16366601
2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.
Tsu H, Chen X, Chen CT, Lee SJ, Chang CN, Kao KH, Coumar MS, Yeh YT, Chien CH, Wang HS, Lin KT, Chang YY, Wu SH, Chen YS, Lu IL, Wu SY, Tsai TY, Chen WC, Hsieh HP, Chao YS, Jiaang WT. Tsu H, et al. Among authors: hsieh hp. J Med Chem. 2006 Jan 12;49(1):373-80. doi: 10.1021/jm0507781. J Med Chem. 2006. PMID: 16392822
3-[2-((2S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes.
Coumar MS, Chang CN, Chen CT, Chen X, Chien CH, Tsai TY, Cheng JH, Wu HY, Han CH, Wu SH, Huang YW, Hsu T, Hsu LJ, Chao YS, Hsieh HP, Jiaang WT. Coumar MS, et al. Among authors: hsieh hp. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1274-9. doi: 10.1016/j.bmcl.2006.12.019. Epub 2006 Dec 12. Bioorg Med Chem Lett. 2007. PMID: 17194587
Aurora kinase inhibitors in preclinical and clinical testing.
Cheung CH, Coumar MS, Hsieh HP, Chang JY. Cheung CH, et al. Among authors: hsieh hp. Expert Opin Investig Drugs. 2009 Apr;18(4):379-98. doi: 10.1517/13543780902806392. Expert Opin Investig Drugs. 2009. PMID: 19335272 Review.
151 results