Elevated truncated oxidized phospholipids as a factor exacerbating ALI in the aging lungs.
Ke Y, Karki P, Kim J, Son S, Berdyshev E, Bochkov VN, Birukova AA, Birukov KG.
Ke Y, et al.
FASEB J. 2019 Mar;33(3):3887-3900. doi: 10.1096/fj.201800981R. Epub 2018 Dec 6.
FASEB J. 2019.
PMID: 30521374
Free PMC article.
These results demonstrate an age-dependent increase in Tr-OxPL production under basal conditions and augmented Tr-OxPL generation upon inflammatory stimulation, suggesting a major role for elevated Tr-OxPLs in more severe ALI and delayed resolution in aging lungs.-Ke, Y …
These results demonstrate an age-dependent increase in Tr-OxPL production under basal conditions and augmented Tr-OxPL generation upon infla …