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The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia.
Toscan CE, McCalmont H, Ashoorzadeh A, Lin X, Fu Z, Doculara L, Kosasih HJ, Cadiz R, Zhou A, Williams S, Evans K, Khalili F, Cai R, Yeats KL, Gifford AJ, Pickford R, Mayoh C, Xie J, Henderson MJ, Trahair TN, Patterson AV, Smaill JB, de Bock CE, Lock RB. Toscan CE, et al. Among authors: doculara l. Blood Cancer J. 2024 Nov 6;14(1):192. doi: 10.1038/s41408-024-01180-x. Blood Cancer J. 2024. PMID: 39505850 Free PMC article.
Circulating Tumor DNA in Pediatric Cancer.
Doculara L, Trahair TN, Bayat N, Lock RB. Doculara L, et al. Front Mol Biosci. 2022 May 12;9:885597. doi: 10.3389/fmolb.2022.885597. eCollection 2022. Front Mol Biosci. 2022. PMID: 35647029 Free PMC article. Review.
Sensitive Measurement of Minimal Residual Disease in Blood by HAT-PCR.
Latham S, Hughes E, Budgen B, Ross D, Greenwood M, Bradstock K, Dalla-Pozza L, Huang L, Law T, Doculara L, Venn N, Ullah S, Sutton R, Morley AA. Latham S, et al. Among authors: doculara l. J Mol Diagn. 2022 Jun;24(6):632-641. doi: 10.1016/j.jmoldx.2022.03.007. Epub 2022 Apr 14. J Mol Diagn. 2022. PMID: 35430373 Free article. Clinical Trial.
miR-139-5p Modulates Radiotherapy Resistance in Breast Cancer by Repressing Multiple Gene Networks of DNA Repair and ROS Defense.
Pajic M, Froio D, Daly S, Doculara L, Millar E, Graham PH, Drury A, Steinmann A, de Bock CE, Boulghourjian A, Zaratzian A, Carroll S, Toohey J, O'Toole SA, Harris AL, Buffa FM, Gee HE, Hollway GE, Molloy TJ. Pajic M, et al. Among authors: doculara l. Cancer Res. 2018 Jan 15;78(2):501-515. doi: 10.1158/0008-5472.CAN-16-3105. Epub 2017 Nov 27. Cancer Res. 2018. PMID: 29180477