Mitchell S - Search Results

1

Systems biology-enabled targeting of NF-κB and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL.

Vareli A, Narayanan HV, Clark H, Jayawant E, Zhou H, Liu Y, Stott L, Simoes F, Hoffmann A, Pepper A, Pepper C, Mitchell S. Vareli A, et al. Among authors: mitchell s. bioRxiv [Preprint]. 2024 Dec 5:2024.11.30.626166. doi: 10.1101/2024.11.30.626166. bioRxiv. 2024. PMID: 39677808 Free PMC article. Preprint.

2

Studying NF-κB signaling with mathematical models.

Mitchell S, Tsui R, Hoffmann A. Mitchell S, et al. Methods Mol Biol. 2015;1280:647-61. doi: 10.1007/978-1-4939-2422-6_38. Methods Mol Biol. 2015. PMID: 25736777

3

Signaling via the NFκB system.

Mitchell S, Vargas J, Hoffmann A. Mitchell S, et al. Wiley Interdiscip Rev Syst Biol Med. 2016 May;8(3):227-41. doi: 10.1002/wsbm.1331. Epub 2016 Mar 16. Wiley Interdiscip Rev Syst Biol Med. 2016. PMID: 26990581 Free PMC article. Review.

4

Identifying Noise Sources governing cell-to-cell variability.

Mitchell S, Hoffmann A. Mitchell S, et al. Curr Opin Syst Biol. 2018 Apr;8:39-45. doi: 10.1016/j.coisb.2017.11.013. Epub 2017 Dec 6. Curr Opin Syst Biol. 2018. PMID: 29623300 Free PMC article.

5

Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB.

Mitchell S, Hoffmann A. Mitchell S, et al. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10592-10597. doi: 10.1073/pnas.1816000116. Epub 2019 May 2. Proc Natl Acad Sci U S A. 2019. PMID: 31048505 Free PMC article.

6

Targeting the Non-Canonical NF-κB Pathway in Chronic Lymphocytic Leukemia and Multiple Myeloma.

Burley TA, Kennedy E, Broad G, Boyd M, Li D, Woo T, West C, Ladikou EE, Ashworth I, Fegan C, Johnston R, Mitchell S, Mackay SP, Pepper AGS, Pepper C. Burley TA, et al. Among authors: mitchell s. Cancers (Basel). 2022 Mar 15;14(6):1489. doi: 10.3390/cancers14061489. Cancers (Basel). 2022. PMID: 35326640 Free PMC article.

7

Elucidation of Focal Adhesion Kinase as a Modulator of Migration and Invasion and as a Potential Therapeutic Target in Chronic Lymphocytic Leukemia.

Burley TA, Hesketh A, Bucca G, Kennedy E, Ladikou EE, Towler BP, Mitchell S, Smith CP, Fegan C, Johnston R, Pepper A, Pepper C. Burley TA, et al. Among authors: mitchell s. Cancers (Basel). 2022 Mar 22;14(7):1600. doi: 10.3390/cancers14071600. Cancers (Basel). 2022. PMID: 35406371 Free PMC article.

8

The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts.

Mitchell S, Tsui R, Tan ZC, Pack A, Hoffmann A. Mitchell S, et al. Sci Signal. 2023 Mar 14;16(776):eabo2838. doi: 10.1126/scisignal.abo2838. Epub 2023 Mar 14. Sci Signal. 2023. PMID: 36917644 Free PMC article. Review.

9

Computational modeling of DLBCL predicts response to BH3-mimetics.

Cloete I, Smith VM, Jackson RA, Pepper A, Pepper C, Vogler M, Dyer MJS, Mitchell S. Cloete I, et al. Among authors: mitchell s. NPJ Syst Biol Appl. 2023 Jun 6;9(1):23. doi: 10.1038/s41540-023-00286-5. NPJ Syst Biol Appl. 2023. PMID: 37280330 Free PMC article.

10

Patient-specific computational models predict prognosis in B cell lymphoma by quantifying pro-proliferative and anti-apoptotic signatures from genetic sequencing data.

Norris R, Jones J, Mancini E, Chevassut T, Simoes FA, Pepper C, Pepper A, Mitchell S. Norris R, et al. Among authors: mitchell s. Blood Cancer J. 2024 Jul 4;14(1):105. doi: 10.1038/s41408-024-01090-y. Blood Cancer J. 2024. PMID: 38965209 Free PMC article.

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