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134 results

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Page 1
Potent antitumor activity of a designed interleukin-21 mimic.
Chun JH, Lim BS, Roy S, Walsh MJ, Abhiraman GC, Zhangxu K, Atajanova T, Revach OY, Clark EC, Li P, Palin CA, Khanna A, Tower S, Kureshi R, Hoffman MT, Sharova T, Lawless A, Cohen S, Boland GM, Nguyen T, Peprah F, Tello JG, Liu SY, Kim CJ, Shin H, Quijano-Rubio A, Jude KM, Gerben S, Murray A, Heine P, DeWitt M, Ulge UY, Carter L, King NP, Silva DA, Kueh HY, Kalia V, Sarkar S, Jenkins RW, Garcia KC, Leonard WJ, Dougan M, Dougan SK, Baker D. Chun JH, et al. Among authors: boland gm. bioRxiv [Preprint]. 2024 Dec 7:2024.12.06.626481. doi: 10.1101/2024.12.06.626481. bioRxiv. 2024. PMID: 39677740 Free PMC article. Preprint.
Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy.
Revach OY, Cicerchia AM, Shorer O, Petrova B, Anderson S, Park J, Chen L, Mehta A, Wright SJ, McNamee N, Tal-Mason A, Cattaneo G, Tiwari P, Xie H, Sweere JM, Cheng LC, Sigal N, Enrico E, Miljkovic M, Evans SA, Nguyen N, Whidden ME, Srinivasan R, Spitzer MH, Sun Y, Sharova T, Lawless AR, Michaud WA, Rasmussen MQ, Fang J, Palin CA, Chen F, Wang X, Ferrone CR, Lawrence DP, Sullivan RJ, Liu D, Sachdeva UM, Sen DR, Flaherty KT, Manguso RT, Bod L, Kellis M, Boland GM, Yizhak K, Yang J, Kanarek N, Sade-Feldman M, Hacohen N, Jenkins RW. Revach OY, et al. Among authors: boland gm. bioRxiv [Preprint]. 2024 Mar 26:2024.02.12.579184. doi: 10.1101/2024.02.12.579184. bioRxiv. 2024. PMID: 38405985 Free PMC article. Preprint.
Immune Responses in Checkpoint Myocarditis Across Heart, Blood, and Tumor.
Blum SM, Zlotoff DA, Smith NP, Kernin IJ, Ramesh S, Zubiri L, Caplin J, Samanta N, Martin SC, Tirard A, Sen P, Song Y, Barth J, Slowikowski K, Nasrallah M, Tantivit J, Manakongtreecheep K, Arnold BY, McGuire J, Pinto CJ, McLoughlin D, Jackson M, Chan P, Lawless A, Sharova T, Nieman LT, Gainor JF, Juric D, Mino-Kenudsen M, Sullivan RJ, Boland GM, Stone JR, Thomas MF, Neilan TG, Reynolds KL, Villani AC. Blum SM, et al. Among authors: boland gm. bioRxiv [Preprint]. 2023 Nov 29:2023.09.15.557794. doi: 10.1101/2023.09.15.557794. bioRxiv. 2023. Update in: Nature. 2024 Dec;636(8041):215-223. doi: 10.1038/s41586-024-08105-5 PMID: 37790460 Free PMC article. Updated. Preprint.
Cancer immunotherapy response persists after lymph node resection.
Zhou H, Menzel L, Baish JW, O'Melia MJ, Darragh LB, Specht E, Effiom DN, Czapla J, Lei PJ, Rajotte JJ, Liu L, Nikmaneshi MR, Razavi MS, Vander Heiden MG, Ubellacker JM, Munn LL, Karam SD, Boland GM, Cohen S, Padera TP. Zhou H, et al. Among authors: boland gm. bioRxiv [Preprint]. 2024 Dec 11:2023.09.19.558262. doi: 10.1101/2023.09.19.558262. bioRxiv. 2024. PMID: 37781599 Free PMC article. Preprint.
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.
Takahashi M, Chong HB, Zhang S, Lazarov MJ, Harry S, Maynard M, White R, Murrey HE, Hilbert B, Neil JR, Gohar M, Ge M, Zhang J, Durr BR, Kryukov G, Tsou CC, Brooijmans N, Alghali ASO, Rubio K, Vilanueva A, Harrison D, Koglin AS, Ojeda S, Karakyriakou B, Healy A, Assaad J, Makram F, Rachman I, Khandelwal N, Tien PC, Popoola G, Chen N, Vordermark K, Richter M, Patel H, Yang TY, Griesshaber H, Hosp T, van den Ouweland S, Hara T, Bussema L, Dong R, Shi L, Rasmussen MQ, Domingues AC, Lawless A, Fang J, Yoda S, Nguyen LP, Reeves SM, Wakefield FN, Acker A, Clark SE, Dubash T, Fisher DE, Maheswaran S, Haber DA, Boland G, Sade-Feldman M, Jenkins R, Hata A, Bardeesy N, Suva ML, Martin B, Liau B, Ott C, Rivera MN, Lawrence MS, Bar-Peled L. Takahashi M, et al. bioRxiv [Preprint]. 2023 Oct 23:2023.10.20.563287. doi: 10.1101/2023.10.20.563287. bioRxiv. 2023. Update in: Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027 PMID: 37961514 Free PMC article. Updated. Preprint.
A Comprehensive Proteogenomic and Spatial Analysis of Innate and Acquired Resistance of Metastatic Melanoma to Immune Checkpoint Blockade Therapies.
Wei S, Du K, Lan H, Yang Z, Deng Y, Wei Z, Frederick DT, Lee J, Labrie M, Tian T, Moll T, Chen Y, Sullivan RJ, Mills G, Boland GM, Flaherty KT, Liu L, Herlyn M, Zhang G. Wei S, et al. Among authors: boland gm. bioRxiv [Preprint]. 2024 Sep 15:2024.09.12.612675. doi: 10.1101/2024.09.12.612675. bioRxiv. 2024. PMID: 39314469 Free PMC article. Preprint.
Stratified analysis identifies HIF-2α as a therapeutic target for highly immune-infiltrated melanomas.
Huang AY, Burke KP, Porter R, Meiger L, Fatouros P, Yang J, Robitschek E, Vokes N, Ricker C, Rosado V, Tarantino G, Chen J, Aprati TJ, Glettig MC, He Y, Wang C, Fu D, Ho LL, Galani K, Freeman GJ, Buchbinder EI, Stephen Hodi F, Kellis M, Boland GM, Sharpe AH, Liu D. Huang AY, et al. Among authors: boland gm. bioRxiv [Preprint]. 2024 Oct 30:2024.10.29.620300. doi: 10.1101/2024.10.29.620300. bioRxiv. 2024. PMID: 39554029 Free PMC article. Preprint.
Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response.
Chen JH, Nieman LT, Spurrell M, Jorgji V, Richieri P, Xu KH, Madhu R, Parikh M, Zamora I, Mehta A, Nabel CS, Freeman SS, Pirl JD, Lu C, Meador CB, Barth JL, Sakhi M, Tang AL, Sarkizova S, Price C, Fernandez NF, Emanuel G, He J, Raay KV, Reeves JW, Yizhak K, Hofree M, Shih A, Sade-Feldman M, Boland GM, Pelka K, Aryee M, Korsunsky I, Mino-Kenudson M, Gainor JF, Hacohen N. Chen JH, et al. Among authors: boland gm. bioRxiv [Preprint]. 2023 Apr 6:2023.04.04.535379. doi: 10.1101/2023.04.04.535379. bioRxiv. 2023. Update in: Nat Immunol. 2024 Apr;25(4):644-658. doi: 10.1038/s41590-024-01792-2 PMID: 37066412 Free PMC article. Updated. Preprint.
Specific oncogene activation of the cell of origin in mucosal melanoma.
Babu S, Chen J, Robitschek E, Baron CS, McConnell A, Wu C, Dedeilia A, Sade-Feldman M, Modhurima R, Manos MP, Chen KY, Cox AM, Ludwig CG, Yang J, Kellis M, Buchbinder EI, Hacohen N, Boland GM, Abraham BJ, Liu D, Zon LI, Insco ML. Babu S, et al. Among authors: boland gm. bioRxiv [Preprint]. 2024 Apr 26:2024.04.22.590595. doi: 10.1101/2024.04.22.590595. bioRxiv. 2024. PMID: 38712250 Free PMC article. Preprint.
A unique interplay of access and selection shapes peritoneal metastasis evolution in colorectal cancer.
Wassenaar EC, Gorelick AN, Hung WT, Cheek DM, Kucukkose E, Lee IH, Blohmer M, Degner S, Giunta P, Wiezer RM, Raicu MG, Ubink I, Klaasen SJ, Lansu N, Watson EV, Corcoran RB, Boland G, Getz G, Kops GJ, Juric D, Lennerz JK, Boerma D, Kranenburg O, Naxerova K. Wassenaar EC, et al. bioRxiv [Preprint]. 2024 Sep 27:2024.09.25.614736. doi: 10.1101/2024.09.25.614736. bioRxiv. 2024. PMID: 39386634 Free PMC article. Preprint.
134 results