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Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog.
Weinberg J, Liu KH, Lee CM, Crandall WJ, Cuevas AR, Druzak SA, Morgan ET, Jarrell ZR, Ortlund EA, Martin GS, Singer G, Strobel FH, Go YM, Jones DP. Weinberg J, et al. Among authors: crandall wj. J Biol Chem. 2024 Dec 13;301(1):108074. doi: 10.1016/j.jbc.2024.108074. Online ahead of print. J Biol Chem. 2024. PMID: 39675709 Free article.
What was old is new again: Phenotypic screening of a unique fungal library yields pyridoxatin, a promising lead against extensively resistant Acinetobacter baumannii (AB5075).
Winter HL, Flores-Bocanegra L, Cank KB, Crandall WJ, Rotich FC, Tillman MN, Todd DA, Graf TN, Raja HA, Pearce CJ, Oberlies NH, Cech NB. Winter HL, et al. Among authors: crandall wj. Phytochem Lett. 2023 Jun;55:88-96. doi: 10.1016/j.phytol.2023.04.002. Epub 2023 Apr 21. Phytochem Lett. 2023. PMID: 37252254 Free PMC article.