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Page 1
2,4-Diaryl-pyrimido[1,2-a]benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and kinase profiling.
Shaldam MA, Hendrychová D, El-Haggar R, Vojáčková V, Majrashi TA, Elkaeed EB, Masurier N, Kryštof V, Tawfik HO, Eldehna WM. Shaldam MA, et al. Among authors: tawfik ho. Eur J Med Chem. 2023 Oct 5;258:115610. doi: 10.1016/j.ejmech.2023.115610. Epub 2023 Jun 27. Eur J Med Chem. 2023. PMID: 37437350
Novel 4-(2-arylidenehydrazineyl)thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico insights.
Elsebaie HA, El-Bastawissy EA, Elberembally KM, Khaleel EF, Badi RM, Shaldam MA, Eldehna WM, Tawfik HO, El-Moselhy TF. Elsebaie HA, et al. Among authors: tawfik ho. Bioorg Chem. 2023 Nov;140:106799. doi: 10.1016/j.bioorg.2023.106799. Epub 2023 Aug 22. Bioorg Chem. 2023. PMID: 37625210
Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles.
Hefny SM, El-Moselhy TF, El-Din N, Giovannuzzi S, Bin Traiki T, Vaali-Mohammed MA, El-Dessouki AM, Yamaguchi K, Sugiura M, Shaldam MA, Supuran CT, Abdulla MH, Eldehna WM, Tawfik HO. Hefny SM, et al. Among authors: tawfik ho. J Med Chem. 2024 May 9;67(9):7406-7430. doi: 10.1021/acs.jmedchem.4c00239. Epub 2024 Apr 20. J Med Chem. 2024. PMID: 38642371
Unveiling the potential of isatin-grafted phenyl-1,2,3-triazole derivatives as dual VEGFR-2/STAT-3 inhibitors: Design, synthesis and biological assessments.
Elsebaie HA, Abdulla MH, Elsayed ZM, Shaldam MA, Tawfik HO, Morsy SN, Vaali Mohammed MA, Bin Traiki T, Elkaeed EB, Abdel-Aziz HA, Eldehna WM. Elsebaie HA, et al. Among authors: tawfik ho. Bioorg Chem. 2024 Oct;151:107626. doi: 10.1016/j.bioorg.2024.107626. Epub 2024 Jul 10. Bioorg Chem. 2024. PMID: 39013242
Identification of indole-grafted pyrazolopyrimidine and pyrazolopyridine derivatives as new anti-cancer agents: Synthesis, biological assessments, and molecular modeling insights.
Eldehna WM, Tawfik HO, Abdulla MH, Nafie MS, Aref H, Shaldam MA, Alhassan NS, Al Obeed O, Elsayed ZM, Abdel-Aziz HA. Eldehna WM, et al. Among authors: tawfik ho. Bioorg Chem. 2024 Dec;153:107804. doi: 10.1016/j.bioorg.2024.107804. Epub 2024 Sep 6. Bioorg Chem. 2024. PMID: 39276491
Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies.
Farouk F, Elmaaty AA, Elkamhawy A, Tawfik HO, Alnajjar R, Abourehab MAS, Saleh MA, Eldehna WM, Al-Karmalawy AA. Farouk F, et al. Among authors: tawfik ho. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2171029. doi: 10.1080/14756366.2023.2171029. J Enzyme Inhib Med Chem. 2023. PMID: 36701269 Free PMC article.
43 results