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Evaluation of a potent LpxC inhibitor for post-exposure prophylaxis treatment of antibiotic-resistant Burkholderia pseudomallei in a murine infection model.
Heine HS, Purcell BK, Duncan C, Miller L, Craig JE, Chase A, Honour L, Vicchiarelli M, Drusano GL, Zhou P. Heine HS, et al. Among authors: zhou p. Antimicrob Agents Chemother. 2024 Dec 13:e0129524. doi: 10.1128/aac.01295-24. Online ahead of print. Antimicrob Agents Chemother. 2024. PMID: 39670750 Free article.
Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens.
Zhao J, Cochrane CS, Najeeb J, Gooden D, Sciandra C, Fan P, Lemaitre N, Newns K, Nicholas RA, Guan Z, Thaden JT, Fowler VG Jr, Spasojevic I, Sebbane F, Toone EJ, Duncan C, Gammans R, Zhou P. Zhao J, et al. Among authors: zhou p. Sci Transl Med. 2023 Aug 9;15(708):eadf5668. doi: 10.1126/scitranslmed.adf5668. Epub 2023 Aug 9. Sci Transl Med. 2023. PMID: 37556556 Free PMC article.
High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.
Titecat M, Liang X, Lee CJ, Charlet A, Hocquet D, Lambert T, Pagès JM, Courcol R, Sebbane F, Toone EJ, Zhou P, Lemaitre N. Titecat M, et al. Among authors: zhou p. J Antimicrob Chemother. 2016 Oct;71(10):2874-82. doi: 10.1093/jac/dkw210. Epub 2016 Jun 20. J Antimicrob Chemother. 2016. PMID: 27330072 Free PMC article.
Adaptive Responses of Pseudomonas aeruginosa to Treatment with Antibiotics.
Wüllner D, Gesper M, Haupt A, Liang X, Zhou P, Dietze P, Narberhaus F, Bandow JE. Wüllner D, et al. Among authors: zhou p. Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0087821. doi: 10.1128/AAC.00878-21. Epub 2021 Nov 8. Antimicrob Agents Chemother. 2022. PMID: 34748386 Free PMC article.
9,659 results