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CXCL12-targeted immunomodulatory gene therapy reduces radiation-induced fibrosis in healthy tissues.
Paget JT, Ward JA, McKean AR, Mansfield DC, McLaughlin M, Kyula-Currie JN, Smith HG, Roulstone V, Li C, Zhou Y, Hardiman T, Grigoriadis A, O'Brien Coon D, Irshad S, Melcher AA, Harrington KJ, Khan A. Paget JT, et al. Among authors: mclaughlin m. Mol Cancer Ther. 2024 Dec 12. doi: 10.1158/1535-7163.MCT-23-0872. Online ahead of print. Mol Cancer Ther. 2024. PMID: 39666014
Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues.
Khan AA, Paget JT, McLaughlin M, Kyula JN, Wilkinson MJ, Pencavel T, Mansfield D, Roulstone V, Seth R, Halle M, Somaiah N, Boult JKR, Robinson SP, Pandha HS, Vile RG, Melcher AA, Harris PA, Harrington KJ. Khan AA, et al. Among authors: mclaughlin m. Sci Transl Med. 2018 Jan 24;10(425):eaar2041. doi: 10.1126/scitranslmed.aar2041. Sci Transl Med. 2018. PMID: 29367346 Free PMC article.
ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment.
Dillon MT, Bergerhoff KF, Pedersen M, Whittock H, Crespo-Rodriguez E, Patin EC, Pearson A, Smith HG, Paget JTE, Patel RR, Foo S, Bozhanova G, Ragulan C, Fontana E, Desai K, Wilkins AC, Sadanandam A, Melcher A, McLaughlin M, Harrington KJ. Dillon MT, et al. Among authors: mclaughlin m. Clin Cancer Res. 2019 Jun 1;25(11):3392-3403. doi: 10.1158/1078-0432.CCR-18-1821. Epub 2019 Feb 15. Clin Cancer Res. 2019. PMID: 30770349 Free PMC article.
PD-1 Blockade Following Isolated Limb Perfusion with Vaccinia Virus Prevents Local and Distant Relapse of Soft-tissue Sarcoma.
Smith HG, Mansfield D, Roulstone V, Kyula-Currie JN, McLaughlin M, Patel RR, Bergerhoff KF, Paget JT, Dillon MT, Khan A, Melcher A, Thway K, Harrington KJ, Hayes AJ. Smith HG, et al. Among authors: mclaughlin m. Clin Cancer Res. 2019 Jun 1;25(11):3443-3454. doi: 10.1158/1078-0432.CCR-18-3767. Epub 2019 Mar 18. Clin Cancer Res. 2019. PMID: 30885937
Optimising measles virus-guided radiovirotherapy with external beam radiotherapy and specific checkpoint kinase 1 inhibition.
Touchefeu Y, Khan AA, Borst G, Zaidi SH, McLaughlin M, Roulstone V, Mansfield D, Kyula J, Pencavel T, Karapanagiotou EM, Clayton J, Federspiel MJ, Russell SJ, Garrett M, Collins I, Harrington KJ. Touchefeu Y, et al. Among authors: mclaughlin m. Radiother Oncol. 2013 Jul;108(1):24-31. doi: 10.1016/j.radonc.2013.05.036. Epub 2013 Jul 9. Radiother Oncol. 2013. PMID: 23849174
1,551 results