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Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia.
Swingle KL, Hamilton AG, Safford HC, Geisler HC, Thatte AS, Palanki R, Murray AM, Han EL, Mukalel AJ, Han X, Joseph RA, Ghalsasi AA, Alameh MG, Weissman D, Mitchell MJ. Swingle KL, et al. Among authors: joseph ra. Nature. 2024 Dec 11. doi: 10.1038/s41586-024-08291-2. Online ahead of print. Nature. 2024. PMID: 39663452
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy.
Swingle KL, Safford HC, Geisler HC, Hamilton AG, Thatte AS, Billingsley MM, Joseph RA, Mrksich K, Padilla MS, Ghalsasi AA, Alameh MG, Weissman D, Mitchell MJ. Swingle KL, et al. Among authors: joseph ra. J Am Chem Soc. 2023 Mar 1;145(8):4691-4706. doi: 10.1021/jacs.2c12893. Epub 2023 Feb 15. J Am Chem Soc. 2023. PMID: 36789893 Free PMC article.
Lipid nanoparticle-mediated RNA delivery for immune cell modulation.
Kim EH, Teerdhala SV, Padilla MS, Joseph RA, Li JJ, Haley RM, Mitchell MJ. Kim EH, et al. Among authors: joseph ra. Eur J Immunol. 2024 Dec;54(12):e2451008. doi: 10.1002/eji.202451008. Epub 2024 Sep 16. Eur J Immunol. 2024. PMID: 39279550 Free PMC article. Review.
Solution biophysics identifies lipid nanoparticle non-sphericity, polydispersity, and dependence on internal ordering for efficacious mRNA delivery.
Padilla MS, Shepherd SJ, Hanna AR, Kurnik M, Zhang X, Chen M, Byrnes J, Yamagata HM, Ricciardi A, Joseph RA, Mrksich K, Issadore D, Gupta K, Mitchell MJ. Padilla MS, et al. Among authors: joseph ra. bioRxiv [Preprint]. 2024 Dec 22:2024.12.19.629496. doi: 10.1101/2024.12.19.629496. bioRxiv. 2024. PMID: 39763759 Free PMC article. Preprint.
47 results