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The psychoplastogens ibogaminalog and ibogainalog induce antidepressant-like activity in naïve and depressed mice by mechanisms involving 5-HT2A receptor activation and serotonergic transmission.
Arias HR, Rudin D, Luethi D, Valenta J, Leśniak A, Czartoryska Z, Olejarz-Maciej A, Doroz-Płonka A, Manetti D, De Deurwaerdère P, Romanelli MN, Handzlik J, Liechti ME, Chagraoui A. Arias HR, et al. Among authors: manetti d. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Dec 9;136:111217. doi: 10.1016/j.pnpbp.2024.111217. Online ahead of print. Prog Neuropsychopharmacol Biol Psychiatry. 2024. PMID: 39662723
Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation.
Targowska-Duda KM, Budzynska B, Michalak A, Wnorowski A, Loland CJ, Maj M, Manetti D, Romanelli MN, Jozwiak K, Biala G, Arias HR. Targowska-Duda KM, et al. Among authors: manetti d. Eur Neuropsychopharmacol. 2021 Nov;52:31-47. doi: 10.1016/j.euroneuro.2021.06.006. Epub 2021 Jul 6. Eur Neuropsychopharmacol. 2021. PMID: 34237657
The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation.
Arias HR, Rudin D, Hines DJ, Contreras A, Gulsevin A, Manetti D, Anouar Y, De Deurwaerdere P, Meiler J, Romanelli MN, Liechti ME, Chagraoui A. Arias HR, et al. Among authors: manetti d. Eur J Pharmacol. 2024 Mar 5;966:176329. doi: 10.1016/j.ejphar.2024.176329. Epub 2024 Jan 20. Eur J Pharmacol. 2024. PMID: 38253116
Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation.
Arias HR, Micheli L, Rudin D, Bento O, Borsdorf S, Ciampi C, Marin P, Ponimaskin E, Manetti D, Romanelli MN, Ghelardini C, Liechti ME, Di Cesare Mannelli L. Arias HR, et al. Among authors: manetti d. Biomed Pharmacother. 2024 Aug;177:116867. doi: 10.1016/j.biopha.2024.116867. Epub 2024 Jun 17. Biomed Pharmacother. 2024. PMID: 38889634 Free article.
The Antinociceptive Activity of (E)-3-(thiophen-2-yl)- N -(p-tolyl)acrylamide in Mice Is Reduced by (E)-3-(furan-2-yl)- N -methyl- N -(p-tolyl)acrylamide Through Opposing Modulatory Mechanisms at the α7 Nicotinic Acetylcholine Receptor.
Arias HR, Tae HS, Micheli L, Yousuf A, Manetti D, Romanelli MN, Ghelardini C, Adams DJ, Di Cesare Mannelli L. Arias HR, et al. Among authors: manetti d. Anesth Analg. 2023 Sep 1;137(3):691-701. doi: 10.1213/ANE.0000000000006461. Epub 2023 Apr 14. Anesth Analg. 2023. PMID: 37058425 Free PMC article.
DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), a Novel Derivative of Ibogamine, Inhibits α7 and α9α10 Nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms.
Tae HS, Ortells MO, Tekarli BJ, Manetti D, Romanelli MN, McIntosh JM, Adams DJ, Arias HR. Tae HS, et al. Among authors: manetti d. ACS Chem Neurosci. 2023 Jul 19;14(14):2537-2547. doi: 10.1021/acschemneuro.3c00212. Epub 2023 Jun 29. ACS Chem Neurosci. 2023. PMID: 37386821
(E)-3-Furan-2-yl-N-p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation.
Arias HR, Ghelardini C, Lucarini E, Tae HS, Yousuf A, Marcovich I, Manetti D, Romanelli MN, Elgoyhen AB, Adams DJ, Di Cesare Mannelli L. Arias HR, et al. Among authors: manetti d. ACS Chem Neurosci. 2020 Nov 4;11(21):3603-3614. doi: 10.1021/acschemneuro.0c00476. Epub 2020 Oct 19. ACS Chem Neurosci. 2020. PMID: 33073974
90 results