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The psychoplastogens ibogaminalog and ibogainalog induce antidepressant-like activity in naïve and depressed mice by mechanisms involving 5-HT2A receptor activation and serotonergic transmission.
Arias HR, Rudin D, Luethi D, Valenta J, Leśniak A, Czartoryska Z, Olejarz-Maciej A, Doroz-Płonka A, Manetti D, De Deurwaerdère P, Romanelli MN, Handzlik J, Liechti ME, Chagraoui A. Arias HR, et al. Among authors: czartoryska z. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Dec 9;136:111217. doi: 10.1016/j.pnpbp.2024.111217. Online ahead of print. Prog Neuropsychopharmacol Biol Psychiatry. 2024. PMID: 39662723