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Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo.
Vaidya AS, Peterson FC, Eckhardt J, Xing Z, Park SY, Dejonghe W, Takeuchi J, Pri-Tal O, Faria J, Elzinga D, Volkman BF, Todoroki Y, Mosquna A, Okamoto M, Cutler SR. Vaidya AS, et al. Among authors: cutler sr. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2108281118. doi: 10.1073/pnas.2108281118. Proc Natl Acad Sci U S A. 2021. PMID: 34531324 Free PMC article.
Chemical Approaches for Improving Plant Water Use.
Vaidya AS, Cutler SR. Vaidya AS, et al. Among authors: cutler sr. Methods Mol Biol. 2022;2462:221-230. doi: 10.1007/978-1-0716-2156-1_17. Methods Mol Biol. 2022. PMID: 35152392
Chemical manipulation of plant water use.
Helander JD, Vaidya AS, Cutler SR. Helander JD, et al. Among authors: cutler sr. Bioorg Med Chem. 2016 Feb 1;24(3):493-500. doi: 10.1016/j.bmc.2015.11.010. Epub 2015 Nov 11. Bioorg Med Chem. 2016. PMID: 26612713 Free article. Review.
Dynamic control of plant water use using designed ABA receptor agonists.
Vaidya AS, Helander JDM, Peterson FC, Elzinga D, Dejonghe W, Kaundal A, Park SY, Xing Z, Mega R, Takeuchi J, Khanderahoo B, Bishay S, Volkman BF, Todoroki Y, Okamoto M, Cutler SR. Vaidya AS, et al. Among authors: cutler sr. Science. 2019 Oct 25;366(6464):eaaw8848. doi: 10.1126/science.aaw8848. Science. 2019. PMID: 31649167
A Rationally Designed Agonist Defines Subfamily IIIA Abscisic Acid Receptors As Critical Targets for Manipulating Transpiration.
Vaidya AS, Peterson FC, Yarmolinsky D, Merilo E, Verstraeten I, Park SY, Elzinga D, Kaundal A, Helander J, Lozano-Juste J, Otani M, Wu K, Jensen DR, Kollist H, Volkman BF, Cutler SR. Vaidya AS, et al. Among authors: cutler sr. ACS Chem Biol. 2017 Nov 17;12(11):2842-2848. doi: 10.1021/acschembio.7b00650. Epub 2017 Oct 18. ACS Chem Biol. 2017. PMID: 28949512
An orthogonalized PYR1-based CID module with reprogrammable ligand-binding specificity.
Park SY, Qiu J, Wei S, Peterson FC, Beltrán J, Medina-Cucurella AV, Vaidya AS, Xing Z, Volkman BF, Nusinow DA, Whitehead TA, Wheeldon I, Cutler SR. Park SY, et al. Among authors: cutler sr. Nat Chem Biol. 2024 Jan;20(1):103-110. doi: 10.1038/s41589-023-01447-7. Epub 2023 Oct 23. Nat Chem Biol. 2024. PMID: 37872402 Free PMC article.
603 results