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An overview of drug-induced sodium channel blockade and changes in cardiac conduction: Implications for drug safety.
Chaudhary KW, Clancy CE, Yang PC, Pierson JB, Goldin AL, Koerner JE, Wisialowski TA, Valentin JP, Imredy JP, Lagrutta A, Authier S, Kleiman R, Sager PT, Hoffmann P, Pugsley MK. Chaudhary KW, et al. Among authors: authier s. Clin Transl Sci. 2024 Dec;17(12):e70098. doi: 10.1111/cts.70098. Clin Transl Sci. 2024. PMID: 39660576 Free PMC article. Review.
A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium.
Boulay E, Abernathy MM, Chui R, Friedrichs GS, Gendron-Parra N, Greiter-Wilke A, Guillon JM, Koerner JE, Menard A, Steidl-Nichols J, Pierson J, Pugsley MK, Rossman EI, Strauss D, Troncy E, Valentin JP, Wisialowski T, Authier S. Boulay E, et al. Among authors: authier s. Int J Toxicol. 2019 Jan/Feb;38(1):23-32. doi: 10.1177/1091581818813601. Epub 2018 Dec 19. Int J Toxicol. 2019. PMID: 30567462
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As.
Rossman EI, Wisialowski TA, Vargas HM, Valentin JP, Rolf MG, Roche BM, Riley S, Pugsley MK, Nichols J, Li D, Leishman DJ, Kleiman RB, Greiter-Wilke A, Gintant GA, Engwall MJ, Delaunois A, Authier S. Rossman EI, et al. Among authors: authier s. J Pharmacol Toxicol Methods. 2023 Sep-Oct;123:107270. doi: 10.1016/j.vascn.2023.107270. Epub 2023 May 8. J Pharmacol Toxicol Methods. 2023. PMID: 37164235
Can We Panelize Seizure?
Roberts R, Authier S, Mellon RD, Morton M, Suzuki I, Tjalkens RB, Valentin JP, Pierson JB. Roberts R, et al. Among authors: authier s. Toxicol Sci. 2021 Jan 6;179(1):3-13. doi: 10.1093/toxsci/kfaa167. Toxicol Sci. 2021. PMID: 33165543 Free PMC article.
Innovative approaches to cardiovascular safety pharmacology assessment.
Pugsley MK, Winters BR, Koshman YE, Authier S, Foley CM, Hayes ES, Curtis MJ. Pugsley MK, et al. Among authors: authier s. J Pharmacol Toxicol Methods. 2024 Jul-Aug;128:107533. doi: 10.1016/j.vascn.2024.107533. Epub 2024 Jun 28. J Pharmacol Toxicol Methods. 2024. PMID: 38945308
Assessment of corrected JT-peak (JTpc) and Tpeak-to-Tend (TpTec) as proarrhythmia biomarkers in non-human primates: Outcome from a HESI consortium.
Boulay E, Authier S, Bartko T, Greiter-Wilke A, Leishman D, Li D, Nichols JV, Pierson J, Rossman EI, Valentin JP, Vicente J, Walisser J, Troncy E, Wisialowski TA. Boulay E, et al. Among authors: authier s. J Pharmacol Toxicol Methods. 2024 Sep-Oct;129:107543. doi: 10.1016/j.vascn.2024.107543. Epub 2024 Jul 15. J Pharmacol Toxicol Methods. 2024. PMID: 39019200
141 results