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A genome-wide atlas of human cell morphology.
Ramezani M, Bauman J, Singh A, Weisbart E, Yong J, Lozada M, Way GP, Kavari SL, Diaz C, Haghighi M, Batista TM, Pérez-Schindler J, Claussnitzer M, Singh S, Cimini BA, Blainey PC, Carpenter AE, Jan CH, Neal JT. Ramezani M, et al. Among authors: blainey pc. bioRxiv [Preprint]. 2023 Aug 7:2023.08.06.552164. doi: 10.1101/2023.08.06.552164. bioRxiv. 2023. PMID: 37609130 Free PMC article. Preprint.
Compressed phenotypic screens for complex multicellular models and high-content assays.
Mead BE, Kummerlowe C, Liu N, Kattan WE, Cheng T, Cheah JH, Soule CK, Peters J, Lowder KE, Blainey PC, Hahn WC, Cleary B, Bryson B, Winter PS, Raghavan S, Shalek AK. Mead BE, et al. Among authors: blainey pc. bioRxiv [Preprint]. 2023 Jan 23:2023.01.23.525189. doi: 10.1101/2023.01.23.525189. bioRxiv. 2023. PMID: 36747859 Free PMC article. Preprint.
Programmable multi-kilobase RNA editing using CRISPR-mediated trans-splicing.
Borrajo J, Javanmardi K, Griffin J, St Martin SJ, Yao D, Hill K, Blainey PC, Al-Shayeb B. Borrajo J, et al. Among authors: blainey pc. bioRxiv [Preprint]. 2023 Aug 18:2023.08.18.553620. doi: 10.1101/2023.08.18.553620. bioRxiv. 2023. PMID: 37645763 Free PMC article. Preprint.
Scalable, compressed phenotypic screening using pooled perturbations.
Liu N, Kattan WE, Mead BE, Kummerlowe C, Cheng T, Ingabire S, Cheah JH, Soule CK, Vrcic A, McIninch JK, Triana S, Guzman M, Dao TT, Peters JM, Lowder KE, Crawford L, Amini AP, Blainey PC, Hahn WC, Cleary B, Bryson B, Winter PS, Raghavan S, Shalek AK. Liu N, et al. Among authors: blainey pc. Nat Biotechnol. 2024 Oct 7. doi: 10.1038/s41587-024-02403-z. Online ahead of print. Nat Biotechnol. 2024. PMID: 39375446
Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatment.
Zhu M, Frank MW, Radka CD, Jeanfavre S, Xu J, Tse MW, Pacheco JA, Kim JS, Pierce K, Deik A, Hussain FA, Elsherbini J, Hussain S, Xulu N, Khan N, Pillay V, Mitchell CM, Dong KL, Ndung'u T, Clish CB, Rock CO, Blainey PC, Bloom SM, Kwon DS. Zhu M, et al. Among authors: blainey pc. Cell. 2024 Sep 19;187(19):5413-5430.e29. doi: 10.1016/j.cell.2024.07.029. Epub 2024 Aug 19. Cell. 2024. PMID: 39163861 Free PMC article.
Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening.
Gentili M, Carlson RJ, Liu B, Hellier Q, Andrews J, Qin Y, Blainey PC, Hacohen N. Gentili M, et al. Among authors: blainey pc. bioRxiv [Preprint]. 2024 Apr 9:2024.04.07.588166. doi: 10.1101/2024.04.07.588166. bioRxiv. 2024. Update in: Cell Syst. 2024 Dec 18;15(12):1264-1277.e8. doi: 10.1016/j.cels.2024.11.004 PMID: 38645119 Free PMC article. Updated. Preprint.
Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics.
Carlson RJ, Patten JJ, Stefanakis G, Soong BY, Radhakrishnan A, Singh A, Thakur N, Amarasinghe GK, Hacohen N, Basler CF, Leung D, Uhler C, Davey RA, Blainey PC. Carlson RJ, et al. Among authors: blainey pc. bioRxiv [Preprint]. 2024 Apr 7:2024.04.06.588168. doi: 10.1101/2024.04.06.588168. bioRxiv. 2024. PMID: 38617272 Free PMC article. Preprint.
Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens.
Tse MW, Zhu M, Peters B, Hamami E, Chen J, Davis KP, Nitz S, Weller J, Warrier T, Hunt DK, Morales Y, Kawate T, Gaulin JL, Come JH, Hernandez-Bird J, Huo W, Neisewander I, Kiessling LL, Hung DT, Mecsas J, Aldridge BB, Isberg RR, Blainey PC. Tse MW, et al. Among authors: blainey pc. bioRxiv [Preprint]. 2024 Mar 26:2024.03.26.586803. doi: 10.1101/2024.03.26.586803. bioRxiv. 2024. PMID: 38585790 Free PMC article. Preprint.
86 results