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Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity.
Sato N, Goyama S, Chang YH, Miyawaki M, Fujino T, Koide S, Denda T, Liu X, Ueda K, Yamamoto K, Asada S, Takeda R, Yonezawa T, Tanaka Y, Honda H, Ota Y, Shibata T, Sekiya M, Isobe T, Lamagna C, Masuda E, Iwama A, Shimano H, Inoue JI, Miyake K, Kitamura T. Sato N, et al. Among authors: liu x. Nat Cardiovasc Res. 2024 Dec;3(12):1568-1583. doi: 10.1038/s44161-024-00579-w. Epub 2024 Dec 9. Nat Cardiovasc Res. 2024. PMID: 39653824
CHIP-associated mutant ASXL1 in blood cells promotes solid tumor progression.
Liu X, Sato N, Shimosato Y, Wang TW, Denda T, Chang YH, Yabushita T, Fujino T, Asada S, Tanaka Y, Fukuyama T, Enomoto Y, Ota Y, Sakamoto T, Kitamura T, Goyama S. Liu X, et al. Cancer Sci. 2022 Apr;113(4):1182-1194. doi: 10.1111/cas.15294. Epub 2022 Feb 26. Cancer Sci. 2022. PMID: 35133065 Free PMC article.
Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia.
Hayashi Y, Goyama S, Liu X, Tamura M, Asada S, Tanaka Y, Fukuyama T, Wunderlich M, O'Brien E, Mizukawa B, Yamazaki S, Matsumoto A, Yamasaki S, Shibata T, Matsuda K, Sashida G, Takizawa H, Kitamura T. Hayashi Y, et al. Among authors: liu x. Nat Commun. 2019 Oct 25;10(1):4869. doi: 10.1038/s41467-019-12555-1. Nat Commun. 2019. PMID: 31653912 Free PMC article.
IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia.
Liu X, Sato N, Yabushita T, Li J, Jia Y, Tamura M, Asada S, Fujino T, Fukushima T, Yonezawa T, Tanaka Y, Fukuyama T, Tsuchiya A, Shikata S, Iwamura H, Kinouchi C, Komatsu K, Yamasaki S, Shibata T, Sasaki AT, Schibler J, Wunderlich M, O'Brien E, Mizukawa B, Mulloy JC, Sugiura Y, Takizawa H, Shibata T, Miyake K, Kitamura T, Goyama S. Liu X, et al. EMBO Mol Med. 2023 Jan 11;15(1):e15631. doi: 10.15252/emmm.202115631. Epub 2022 Dec 1. EMBO Mol Med. 2023. PMID: 36453131 Free PMC article.
The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.
Yonezawa T, Takahashi H, Shikata S, Liu X, Tamura M, Asada S, Fukushima T, Fukuyama T, Tanaka Y, Sawasaki T, Kitamura T, Goyama S. Yonezawa T, et al. Among authors: liu x. J Biol Chem. 2017 Jul 28;292(30):12528-12541. doi: 10.1074/jbc.M117.785675. Epub 2017 May 23. J Biol Chem. 2017. PMID: 28536267 Free PMC article.
Intra-Arterial Tenecteplase Following Endovascular Reperfusion for Large Vessel Occlusion Acute Ischemic Stroke: The POST-TNK Randomized Clinical Trial.
Huang J, Yang J, Liu C, Li L, Yang D, Guo C, Zeng G, Song J, Ma J, Xu X, Shi X, Yang S, Sun W, Wang Z, Tang Y, Jiang M, Wang L, Cheng X, Luo J, Zhou P, Fang X, Cheng G, Ruan Z, Li J, Liu J, Lei B, Tian Y, Tan X, Yuan G, Wang J, Huang X, Deng S, Jin Z, Zou X, Zhang J, Cheng D, Luo X, Liao J, Miao J, Li Z, Sun Y, Jiang G, Kong D, Jiang S, Wang Z, Wang D, Kaesmacher J, Nguyen TN, Nogueira RG, Saver JL, Chen Y, Zi W; POST-TNK Investigators. Huang J, et al. JAMA. 2025 Jan 13. doi: 10.1001/jama.2024.23466. Online ahead of print. JAMA. 2025. PMID: 39804681
Intra-Arterial Urokinase After Endovascular Reperfusion for Acute Ischemic Stroke: The POST-UK Randomized Clinical Trial.
Liu C, Guo C, Li F, Yu N, Huang J, Peng Z, Kong W, Song J, Liu X, Fan S, Yue C, Chen B, Zheng C, Yuan X, Sheng J, Wu Y, Sun B, Zhao Z, Zhu M, Han L, Shi Q, Xia Z, Shang X, Li F, Li R, Yue F, Jiang S, Song D, Song M, Shan Y, Ding C, Yao L, Yang Y, Chen J, He W, Pan F, Zhang W, Cai T, Han S, Li W, Li G, Gong C, Huang L, Huang C, Wang D, Kaesmacher J, Nguyen TN, Nogueira RG, Saver JL, Zi W, Chen Y, Yang Q; POST-UK investigators. Liu C, et al. Among authors: liu x. JAMA. 2025 Jan 13. doi: 10.1001/jama.2024.23480. Online ahead of print. JAMA. 2025. PMID: 39804674
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