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Page 1
Dysregulation of MMP2-dependent TGF-ß2 activation impairs fibrous cap formation in type 2 diabetes-associated atherosclerosis.
Singh P, Sun J, Cavalera M, Al-Sharify D, Matthes F, Barghouth M, Tengryd C, Dunér P, Persson A, Sundius L, Nitulescu M, Bengtsson E, Rattik S, Engelbertsen D, Orho-Melander M, Nilsson J, Monaco C, Goncalves I, Edsfeldt A. Singh P, et al. Among authors: rattik s. Nat Commun. 2024 Dec 9;15(1):10464. doi: 10.1038/s41467-024-50753-8. Nat Commun. 2024. PMID: 39653743 Free PMC article.
IL1RAP Blockade With a Monoclonal Antibody Reduces Cardiac Inflammation and Preserves Heart Function in Viral and Autoimmune Myocarditis.
Lema DA, Jakobsson G, Daoud A, Elias D, Talor MV, Rattik S, Grönberg C, Kalinoski H, Jaensson Gyllenbäck E, Wang N, Liberg D, Schiopu A, Čiháková D. Lema DA, et al. Among authors: rattik s. Circ Heart Fail. 2024 Dec;17(12):e011729. doi: 10.1161/CIRCHEARTFAILURE.124.011729. Epub 2024 Nov 8. Circ Heart Fail. 2024. PMID: 39513273 Free PMC article.
Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling.
Fields JK, Gyllenbäck EJ, Bogacz M, Obi J, Birkedal GS, Sjöström K, Maravillas K, Grönberg C, Rattik S, Kihn K, Flowers M, Smith AK, Hansen N, Fioretos T, Huyhn C, Liberg D, Deredge D, Sundberg EJ. Fields JK, et al. Among authors: rattik s. Cell Rep. 2024 May 28;43(5):114099. doi: 10.1016/j.celrep.2024.114099. Epub 2024 Apr 17. Cell Rep. 2024. PMID: 38636519 Free PMC article.
Combined inhibition of IL-1, IL-33 and IL-36 signalling by targeting IL1RAP ameliorates skin and lung fibrosis in preclinical models of systemic sclerosis.
Grönberg C, Rattik S, Tran-Manh C, Zhou X, Rius Rigau A, Li YN, Györfi AH, Dickel N, Kunz M, Kreuter A, Matei EA, Zhu H, Skoog P, Liberg D, Distler JH, Trinh-Minh T. Grönberg C, et al. Among authors: rattik s. Ann Rheum Dis. 2024 Aug 27;83(9):1156-1168. doi: 10.1136/ard-2023-225158. Ann Rheum Dis. 2024. PMID: 38594058 Free PMC article.
Interleukin-1 receptor accessory protein blockade limits the development of atherosclerosis and reduces plaque inflammation.
Mulholland M, Depuydt MAC, Jakobsson G, Ljungcrantz I, Grentzmann A, To F, Bengtsson E, Jaensson Gyllenbäck E, Grönberg C, Rattik S, Liberg D, Schiopu A, Björkbacka H, Kuiper J, Bot I, Slütter B, Engelbertsen D. Mulholland M, et al. Among authors: rattik s. Cardiovasc Res. 2024 May 7;120(6):581-595. doi: 10.1093/cvr/cvae046. Cardiovasc Res. 2024. PMID: 38563353 Free PMC article.
Immune responses against oxidized LDL as possible targets for prevention of atherosclerosis in systemic lupus erythematosus.
Yao Mattisson I, Rattik S, Björkbacka H, Ljungcrantz I, Terrinoni M, Lebens M, Holmgren J, Fredrikson GN, Gullstrand B, Bengtsson AA, Nilsson J, Wigren M. Yao Mattisson I, et al. Among authors: rattik s. Vascul Pharmacol. 2021 Oct;140:106863. doi: 10.1016/j.vph.2021.106863. Epub 2021 Apr 15. Vascul Pharmacol. 2021. PMID: 33857652 Free article.
Liver X receptors are required for thymic resilience and T cell output.
Chan CT, Fenn AM, Harder NK, Mindur JE, McAlpine CS, Patel J, Valet C, Rattik S, Iwamoto Y, He S, Anzai A, Kahles F, Poller WC, Janssen H, Wong LP, Fernandez-Hernando C, Koolbergen DR, van der Laan AM, Yvan-Charvet L, Sadreyev RI, Nahrendorf M, Westerterp M, Tall AR, Gustafsson JA, Swirski FK. Chan CT, et al. Among authors: rattik s. J Exp Med. 2020 Oct 5;217(10):e20200318. doi: 10.1084/jem.20200318. J Exp Med. 2020. PMID: 32716519 Free PMC article.
Increased lymphocyte activation and atherosclerosis in CD47-deficient mice.
Engelbertsen D, Autio A, Verwilligen RAF, Depuydt MAC, Newton G, Rattik S, Levinsohn E, Saggu G, Jarolim P, Wang H, Velazquez F, Lichtman AH, Luscinskas FW. Engelbertsen D, et al. Among authors: rattik s. Sci Rep. 2019 Jul 23;9(1):10608. doi: 10.1038/s41598-019-46942-x. Sci Rep. 2019. PMID: 31337788 Free PMC article.
28 results