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102 results

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Page 1
Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation.
Shah V, Giotopoulos G, Osaki H, Meyerhöfer M, Meduri E, Gallego-Crespo A, Behrendt MA, Saura-Pañella M, Tarkar A, Schubert B, Yun H, Horton SJ, Agrawal-Singh S Dr, Hähnel PS, Basheer F, Lugo D, Eleftheriadou I, Barbash O, Dhar A, Kühn M, Guezguez B, Theobald M, Kindler T, Gallipoli P, Yeh PS, Dawson MA, Prinjha RK, Huntly BJ, Sasca D. Shah V, et al. Among authors: kindler t. Blood. 2024 Dec 9:blood.2022019306. doi: 10.1182/blood.2022019306. Online ahead of print. Blood. 2024. PMID: 39651888
SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia.
Sasca D, Hähnel PS, Szybinski J, Khawaja K, Kriege O, Pante SV, Bullinger L, Strand S, Strand D, Theobald M, Kindler T. Sasca D, et al. Among authors: kindler t. Blood. 2014 Jul 3;124(1):121-33. doi: 10.1182/blood-2013-11-538819. Epub 2014 May 22. Blood. 2014. PMID: 24855208 Free article.
NCAM1 (CD56) promotes leukemogenesis and confers drug resistance in AML.
Sasca D, Szybinski J, Schüler A, Shah V, Heidelberger J, Haehnel PS, Dolnik A, Kriege O, Fehr EM, Gebhardt WH, Reid G, Scholl C, Theobald M, Bullinger L, Beli P, Kindler T. Sasca D, et al. Among authors: kindler t. Blood. 2019 May 23;133(21):2305-2319. doi: 10.1182/blood-2018-12-889725. Epub 2019 Feb 27. Blood. 2019. PMID: 30814062 Free article.
Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition.
Dzama MM, Steiner M, Rausch J, Sasca D, Schönfeld J, Kunz K, Taubert MC, McGeehan GM, Chen CW, Mupo A, Hähnel P, Theobald M, Kindler T, Koche RP, Vassiliou GS, Armstrong SA, Kühn MWM. Dzama MM, et al. Among authors: kindler t. Blood. 2020 Nov 19;136(21):2442-2456. doi: 10.1182/blood.2020005037. Blood. 2020. PMID: 32589720 Free PMC article.
Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis.
Spiecker L, Witte I, Mehlig J, Shah V, Meyerhöfer M, Haehnel PS, Petermann V, Schüler A, More P, Cabezas-Wallscheid N, Horke S, Pautz A, Daiber A, Sasca D, Kindler T, Kleinert H. Spiecker L, et al. Among authors: kindler t. Oxid Med Cell Longev. 2021 Jun 25;2021:3917028. doi: 10.1155/2021/3917028. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34257800 Free PMC article.
A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML.
Breitenbuecher F, Markova B, Kasper S, Carius B, Stauder T, Böhmer FD, Masson K, Rönnstrand L, Huber C, Kindler T, Fischer T. Breitenbuecher F, et al. Among authors: kindler t. Blood. 2009 Apr 23;113(17):4063-73. doi: 10.1182/blood-2007-11-126664. Epub 2009 Jan 14. Blood. 2009. PMID: 19144992 Free article.
Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain.
Heidel F, Solem FK, Breitenbuecher F, Lipka DB, Kasper S, Thiede MH, Brandts C, Serve H, Roesel J, Giles F, Feldman E, Ehninger G, Schiller GJ, Nimer S, Stone RM, Wang Y, Kindler T, Cohen PS, Huber C, Fischer T. Heidel F, et al. Among authors: kindler t. Blood. 2006 Jan 1;107(1):293-300. doi: 10.1182/blood-2005-06-2469. Epub 2005 Sep 8. Blood. 2006. PMID: 16150941 Free article.
102 results