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Fluorescence based live cell imaging identifies exon 14 skipped hepatocyte growth factor receptor (MET) degraders.
Mallareddy JR, Yang L, Lin WH, Feathers R, Ayers-Ringler J, Tolosa E, Kizhake AG, Kizhake S, Kubica SP, Boghean L, Alvarez S, Naldrett MJ, Singh S, Rana S, Zahid M, Schaefer-Klein J, Roden A, Kosari F, Anastasiadis PZ, Borad M, Natarajan A, Mansfield AS. Mallareddy JR, et al. Among authors: singh s. bioRxiv [Preprint]. 2024 Nov 25:2024.11.22.624922. doi: 10.1101/2024.11.22.624922. bioRxiv. 2024. PMID: 39651287 Free PMC article. Preprint.
Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy.
Sagar S, Singh S, Mallareddy JR, Sonawane YA, Napoleon JV, Rana S, Contreras JI, Rajesh C, Ezell EL, Kizhake S, Garrison JC, Radhakrishnan P, Natarajan A. Sagar S, et al. Among authors: singh s. Eur J Med Chem. 2021 Oct 15;222:113579. doi: 10.1016/j.ejmech.2021.113579. Epub 2021 May 30. Eur J Med Chem. 2021. PMID: 34098465 Free PMC article.
Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth.
Napoleon JV, Sagar S, Kubica SP, Boghean L, Kour S, King HM, Sonawane YA, Crawford AJ, Gautam N, Kizhake S, Bialk PA, Kmiec E, Mallareddy JR, Patil PP, Rana S, Singh S, Prahlad J, Grandgenett PM, Borgstahl GEO, Ghosal G, Alnouti Y, Hollingsworth MA, Radhakrishnan P, Natarajan A. Napoleon JV, et al. Among authors: singh s. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2115071119. doi: 10.1073/pnas.2115071119. Epub 2022 Apr 27. Proc Natl Acad Sci U S A. 2022. PMID: 35476515 Free PMC article.
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