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Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining.
Godinez-Macias KP, Chen D, Wallis JL, Siegel MG, Adam A, Bopp S, Carolino K, Coulson LB, Durst G, Thathy V, Esherick L, Farringer MA, Flannery EL, Forte B, Liu T, Magalhaes LG, Gupta AK, Istvan ES, Jiang T, Kumpornsin K, Lobb K, McLean K, Moura IMR, Okombo J, Payne NC, Plater A, Rao SPS, Siqueira-Neto JL, Somsen BA, Summers RL, Zhang R, Gilson MK, Gamo FJ, Campo B, Baragaña B, Duffy J, Gilbert IH, Lukens AK, Dechering KJ, Niles JC, McNamara CW, Cheng X, Birkholtz LM, Bronkhorst AW, Fidock DA, Wirth DF, Goldberg DE, Lee MCS, Winzeler EA. Godinez-Macias KP, et al. Among authors: bopp s. Res Sq [Preprint]. 2024 Nov 26:rs.3.rs-5412515. doi: 10.21203/rs.3.rs-5412515/v1. Res Sq. 2024. PMID: 39649165 Free PMC article. Preprint.
Validation of isoleucine utilization targets in Plasmodium falciparum.
Istvan ES, Dharia NV, Bopp SE, Gluzman I, Winzeler EA, Goldberg DE. Istvan ES, et al. Among authors: bopp se. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1627-32. doi: 10.1073/pnas.1011560108. Epub 2011 Jan 4. Proc Natl Acad Sci U S A. 2011. PMID: 21205898 Free PMC article.
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.
Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, Arriaga I, Bopp S, Corey VC, Gnädig NF, Coburn-Flynn O, Reimer C, Gupta P, Murithi JM, Moura PA, Fuchs O, Sasaki E, Kim SW, Teng CH, Wang LT, Akidil A, Adjalley S, Willis PA, Siegel D, Tanaseichuk O, Zhong Y, Zhou Y, Llinás M, Ottilie S, Gamo FJ, Lee MCS, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA. Cowell AN, et al. Among authors: bopp s. Science. 2018 Jan 12;359(6372):191-199. doi: 10.1126/science.aan4472. Science. 2018. PMID: 29326268 Free PMC article.
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.
Bopp S, Pasaje CFA, Summers RL, Magistrado-Coxen P, Schindler KA, Corpas-Lopez V, Yeo T, Mok S, Dey S, Smick S, Nasamu AS, Demas AR, Milne R, Wiedemar N, Corey V, Gomez-Lorenzo MG, Franco V, Early AM, Lukens AK, Milner D, Furtado J, Gamo FJ, Winzeler EA, Volkman SK, Duffey M, Laleu B, Fidock DA, Wyllie S, Niles JC, Wirth DF. Bopp S, et al. Nat Commun. 2023 Mar 16;14(1):1455. doi: 10.1038/s41467-023-36921-2. Nat Commun. 2023. PMID: 36927839 Free PMC article.
CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs.
Ng CL, Siciliano G, Lee MC, de Almeida MJ, Corey VC, Bopp SE, Bertuccini L, Wittlin S, Kasdin RG, Le Bihan A, Clozel M, Winzeler EA, Alano P, Fidock DA. Ng CL, et al. Among authors: bopp se. Mol Microbiol. 2016 Aug;101(3):381-93. doi: 10.1111/mmi.13397. Epub 2016 May 7. Mol Microbiol. 2016. PMID: 27073104 Free PMC article.
Identification of pathogen genomic variants through an integrated pipeline.
Manary MJ, Singhakul SS, Flannery EL, Bopp SE, Corey VC, Bright AT, McNamara CW, Walker JR, Winzeler EA. Manary MJ, et al. Among authors: bopp se. BMC Bioinformatics. 2014 Mar 3;15:63. doi: 10.1186/1471-2105-15-63. BMC Bioinformatics. 2014. PMID: 24589256 Free PMC article.
148 results