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Patient-specific hiPSC-derived cardiomyocytes indicate allelic and contractile imbalance as pathogenic factor in early-stage Hypertrophic Cardiomyopathy.
Weber N, Montag J, Kowalski K, Iorga B, de la Roche J, Holler T, Wojciechowski D, Wendland M, Radocaj A, Mayer AK, Brunkhorst A, Osten F, Burkart V, Piep B, Bodenschatz A, Gibron P, Schwanke K, Franke A, Thiemann S, Koroleva A, Pfanne A, Konsanke M, Fiedler J, Hegermann J, Wrede C, Mühlfeld C, Chichkov B, Fischer M, Thum T, Francino A, Martin U, Meißner J, Zweigerdt R, Kraft T. Weber N, et al. Among authors: piep b. J Mol Cell Cardiol. 2024 Dec 7;198:112-125. doi: 10.1016/j.yjmcc.2024.11.007. Online ahead of print. J Mol Cell Cardiol. 2024. PMID: 39647438 Free article.
Stiff matrix induces switch to pure β-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes.
Weber N, Schwanke K, Greten S, Wendland M, Iorga B, Fischer M, Geers-Knörr C, Hegermann J, Wrede C, Fiedler J, Kempf H, Franke A, Piep B, Pfanne A, Thum T, Martin U, Brenner B, Zweigerdt R, Kraft T. Weber N, et al. Among authors: piep b. Basic Res Cardiol. 2016 Nov;111(6):68. doi: 10.1007/s00395-016-0587-9. Epub 2016 Oct 14. Basic Res Cardiol. 2016. PMID: 27743117
Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms.
Iorga B, Schwanke K, Weber N, Wendland M, Greten S, Piep B, Dos Remedios CG, Martin U, Zweigerdt R, Kraft T, Brenner B. Iorga B, et al. Among authors: piep b. Front Physiol. 2018 Jan 19;8:1111. doi: 10.3389/fphys.2017.01111. eCollection 2017. Front Physiol. 2018. PMID: 29403388 Free PMC article.
Advanced Single-Cell Mapping Reveals that in hESC Cardiomyocytes Contraction Kinetics and Action Potential Are Independent of Myosin Isoform.
Weber N, Kowalski K, Holler T, Radocaj A, Fischer M, Thiemann S, de la Roche J, Schwanke K, Piep B, Peschel N, Krumm U, Lingk A, Wendland M, Greten S, Schmitto JD, Ismail I, Warnecke G, Zywietz U, Chichkov B, Meißner J, Haverich A, Martin U, Brenner B, Zweigerdt R, Kraft T. Weber N, et al. Among authors: piep b. Stem Cell Reports. 2020 May 12;14(5):788-802. doi: 10.1016/j.stemcr.2020.03.015. Epub 2020 Apr 16. Stem Cell Reports. 2020. PMID: 32302556 Free PMC article.
Transcriptional bursts and heterogeneity among cardiomyocytes in hypertrophic cardiomyopathy.
Burkart V, Kowalski K, Aldag-Niebling D, Beck J, Frick DA, Holler T, Radocaj A, Piep B, Zeug A, Hilfiker-Kleiner D, Dos Remedios CG, van der Velden J, Montag J, Kraft T. Burkart V, et al. Among authors: piep b. Front Cardiovasc Med. 2022 Aug 23;9:987889. doi: 10.3389/fcvm.2022.987889. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 36082122 Free PMC article.
Myosin expression and contractile function are altered by replating stem cell-derived cardiomyocytes.
Osten F, Weber N, Wendland M, Holler T, Piep B, Kröhn S, Teske J, Bodenschatz AK, Devadas SB, Menge KS, Chatterjee S, Schwanke K, Kosanke M, Montag J, Thum T, Zweigerdt R, Kraft T, Iorga B, Meissner JD. Osten F, et al. Among authors: piep b. J Gen Physiol. 2023 Nov 6;155(11):e202313377. doi: 10.1085/jgp.202313377. Epub 2023 Sep 1. J Gen Physiol. 2023. PMID: 37656049 Free PMC article.
Protein-free media for cardiac differentiation of hPSCs in 2000 mL suspension culture.
Kriedemann N, Manstein F, Hernandez-Bautista CA, Ullmann K, Triebert W, Franke A, Mertens M, Stein ICAP, Leffler A, Witte M, Askurava T, Fricke V, Gruh I, Piep B, Kowalski K, Kraft T, Zweigerdt R. Kriedemann N, et al. Among authors: piep b. Stem Cell Res Ther. 2024 Jul 18;15(1):213. doi: 10.1186/s13287-024-03826-w. Stem Cell Res Ther. 2024. PMID: 39020441 Free PMC article.
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