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Page 1
Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent "Type V" Kinase Inhibitors.
Wittlinger F, Chitnis SP, Pham CD, Damghani T, Patel KB, Möllers M, Schaeffner IK, Abidakun OA, Deng MQ, Ogboo BC, Rasch A, Beyett TS, Buckley B, Feru F, Shaurova T, Knappe C, Eck MJ, Hershberger PA, Scott DA, Brandt AL, Laufer SA, Heppner DE. Wittlinger F, et al. Among authors: ogboo bc. J Med Chem. 2024 Dec 12;67(23):21438-21469. doi: 10.1021/acs.jmedchem.4c02311. Epub 2024 Dec 3. J Med Chem. 2024. PMID: 39626019
Demystifying Functional Parameters for Irreversible Enzyme Inhibitors.
Heppner DE, Ogboo BC, Urul DA, May EW, Schaefer EM, Murkin AS, Gehringer M. Heppner DE, et al. Among authors: ogboo bc. J Med Chem. 2024 Sep 12;67(17):14693-14696. doi: 10.1021/acs.jmedchem.4c01721. Epub 2024 Aug 8. J Med Chem. 2024. PMID: 39115869 No abstract available.
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.
Wittlinger F, Ogboo BC, Shevchenko E, Damghani T, Pham CD, Schaeffner IK, Oligny BT, Chitnis SP, Beyett TS, Rasch A, Buckley B, Urul DA, Shaurova T, May EW, Schaefer EM, Eck MJ, Hershberger PA, Poso A, Laufer SA, Heppner DE. Wittlinger F, et al. Among authors: ogboo bc. Commun Chem. 2024 Feb 20;7(1):38. doi: 10.1038/s42004-024-01108-3. Commun Chem. 2024. PMID: 38378740 Free PMC article.
Synthesis, Structure, Hirshfeld Surface Analysis, Non-Covalent Interaction, and In Silico Studies of 4-Hydroxy-1-[(4-Nitrophenyl)Sulfonyl]Pyrrolidine-2-Carboxyllic Acid.
Ugwu DI, Eze FU, Ezeorah CJ, Rhyman L, Ramasami P, Tania G, Eze CC, Uzoewulu CP, Ogboo BC, Okpareke OC. Ugwu DI, et al. Among authors: ogboo bc. J Chem Crystallogr. 2023 Mar 9:1-14. doi: 10.1007/s10870-023-00978-0. Online ahead of print. J Chem Crystallogr. 2023. PMID: 37362239 Free PMC article.
Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
Heppner DE, Wittlinger F, Beyett TS, Shaurova T, Urul DA, Buckley B, Pham CD, Schaeffner IK, Yang B, Ogboo BC, May EW, Schaefer EM, Eck MJ, Laufer SA, Hershberger PA. Heppner DE, et al. Among authors: ogboo bc. ACS Med Chem Lett. 2022 Nov 10;13(12):1856-1863. doi: 10.1021/acsmedchemlett.2c00213. eCollection 2022 Dec 8. ACS Med Chem Lett. 2022. PMID: 36518696 Free PMC article.
Architecture of the NADPH oxidase family of enzymes.
Ogboo BC, Grabovyy UV, Maini A, Scouten S, van der Vliet A, Mattevi A, Heppner DE. Ogboo BC, et al. Redox Biol. 2022 Jun;52:102298. doi: 10.1016/j.redox.2022.102298. Epub 2022 Mar 18. Redox Biol. 2022. PMID: 35334249 Free PMC article. Review.