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Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis.
Kasparkova J, Hernández-García A, Kostrhunova H, Goicuría M, Novohradsky V, Bautista D, Markova L, Santana MD, Brabec V, Ruiz J. Kasparkova J, et al. Among authors: kostrhunova h. J Med Chem. 2024 Jan 11;67(1):691-708. doi: 10.1021/acs.jmedchem.3c01978. Epub 2023 Dec 23. J Med Chem. 2024. PMID: 38141031 Free PMC article.
N-Indolyl diiron vinyliminium complexes exhibit antiproliferative effects in cancer cells associated with disruption of mitochondrial homeostasis, ROS scavenging, and antioxidant activity.
Bresciani G, Cervinka J, Kostrhunova H, Biancalana L, Bortoluzzi M, Pampaloni G, Novohradsky V, Brabec V, Marchetti F, Kasparkova J. Bresciani G, et al. Among authors: kostrhunova h. Chem Biol Interact. 2023 Nov 1;385:110742. doi: 10.1016/j.cbi.2023.110742. Epub 2023 Oct 5. Chem Biol Interact. 2023. PMID: 37802407
Multitargeting Prodrugs that Release Oxaliplatin, Doxorubicin and Gemcitabine are Potent Inhibitors of Tumor Growth and Effective Inducers of Immunogenic Cell Death.
Sarkar A, Novohradsky V, Maji M, Babu T, Markova L, Kostrhunova H, Kasparkova J, Gandin V, Brabec V, Gibson D. Sarkar A, et al. Among authors: kostrhunova h. Angew Chem Int Ed Engl. 2023 Oct 16;62(42):e202310774. doi: 10.1002/anie.202310774. Epub 2023 Sep 12. Angew Chem Int Ed Engl. 2023. PMID: 37646232
Platinum(IV) Derivatives of [Pt(1S,2S-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells.
Kostrhunova H, McGhie BS, Markova L, Novakova O, Kasparkova J, Aldrich-Wright JR, Brabec V. Kostrhunova H, et al. J Med Chem. 2023 Jun 22;66(12):7894-7908. doi: 10.1021/acs.jmedchem.3c00269. Epub 2023 Jun 7. J Med Chem. 2023. PMID: 37285472 Free PMC article.
64 results