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A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T helper cell signaling, differentiation and epigenetic remodeling.
Golec DP, Gazzinelli-Guimaraes P, Chauss D, Nagashima H, Yu K, Hill T, Nivelo L, Cannons JL, Perry J, Joshi I, Pereira N, Oliveira FMS, Cruz AC, Druey KM, Lack JB, Nutman TB, Villarino AV, O'Shea JJ, Afzali B, Schwartzberg PL. Golec DP, et al. Among authors: druey km. bioRxiv [Preprint]. 2024 Nov 2:2024.10.28.620691. doi: 10.1101/2024.10.28.620691. bioRxiv. 2024. PMID: 39803425 Free PMC article. Preprint.
N-cadherin antagonism is bronchoprotective in severe asthma models.
Pereira NL, Schaible N, Desai A, Chan EC, Ablooglu AJ, Capuano J, Lin E, An Z, Gebski E, Jester W, Ganesan S, Balenga N, Koziol-White C, Panettieri RA Jr, Choudhury S, Krishnan R, Druey KM. Pereira NL, et al. Among authors: druey km. Sci Adv. 2024 Nov 29;10(48):eadp8872. doi: 10.1126/sciadv.adp8872. Epub 2024 Nov 29. Sci Adv. 2024. PMID: 39612338 Free PMC article.
Systemic capillary leak syndrome.
Druey KM, Arnaud L, Parikh SM. Druey KM, et al. Nat Rev Dis Primers. 2024 Nov 14;10(1):86. doi: 10.1038/s41572-024-00571-5. Nat Rev Dis Primers. 2024. PMID: 39543164 Review.
PARP15 Is a Susceptibility Locus for Clarkson Disease (Monoclonal Gammopathy-Associated Systemic Capillary Leak Syndrome).
Chan EC, Ablooglu AJ, Ghosh CC, Desai A, Schaible N, Chen X, Zhao M, Olano MR, Ganesan S, Lack JB, Krishnan R, Parikh SM, Druey KM. Chan EC, et al. Among authors: druey km. Arterioscler Thromb Vasc Biol. 2024 Dec;44(12):2628-2646. doi: 10.1161/ATVBAHA.124.321522. Epub 2024 Oct 31. Arterioscler Thromb Vasc Biol. 2024. PMID: 39479769 Free article.
Germline mutations in a G protein identify signaling cross-talk in T cells.
Ham H, Jing H, Lamborn IT, Kober MM, Koval A, Berchiche YA, Anderson DE, Druey KM, Mandl JN, Isidor B, Ferreira CR, Freeman AF, Ganesan S, Karsak M, Mustillo PJ, Teo J, Zolkipli-Cunningham Z, Chatron N, Lecoquierre F, Oler AJ, Schmid JP, Kuhns DB, Xu X, Hauck F, Al-Herz W, Wagner M, Terhal PA, Muurinen M, Barlogis V, Cruz P, Danielson J, Stewart H, Loid P, Rading S, Keren B, Pfundt R, Zarember KA, Vill K, Potocki L, Olivier KN, Lesca G, Faivre L, Wong M, Puel A, Chou J, Tusseau M, Moutsopoulos NM, Matthews HF, Simons C, Taft RJ, Soldatos A, Masle-Farquhar E, Pittaluga S, Brink R, Fink DL, Kong HH, Kabat J, Kim WS, Bierhals T, Meguro K, Hsu AP, Gu J, Stoddard J, Banos-Pinero B, Slack M, Trivellin G, Mazel B, Soomann M, Li S, Watts VJ, Stratakis CA, Rodriguez-Quevedo MF, Bruel AL, Lipsanen-Nyman M, Saultier P, Jain R, Lehalle D, Torres D, Sullivan KE, Barbarot S, Neu A, Duffourd Y, Similuk M, McWalter K, Blanc P, Bézieau S, Jin T, Geha RS, Casanova JL, Makitie OM, Kubisch C, Edery P, Christodoulou J, Germain RN, Goodnow CC, Sakmar TP, Billadeau DD, Küry S, Katanaev VL, Zhang Y, Lenardo MJ, Su HC. Ham H, et al. Among authors: druey km. Science. 2024 Sep 20;385(6715):eadd8947. doi: 10.1126/science.add8947. Epub 2024 Sep 20. Science. 2024. PMID: 39298586
The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets.
Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA, Ahlers-Dannen KE, Alqinyah M, Arumugam TV, Bodle C, Dagner JB, Chakravarti B, Choudhuri SP, Druey KM, Fisher RA, Gerber KJ, Hepler JR, Hooks SB, Kantheti HS, Karaj B, Layeghi-Ghalehsoukhteh S, Lee JK, Luo Z, Martemyanov K, Mascarenhas LD, McNabb H, Montañez-Miranda C, Ogujiofor O, Phan H, Roman DL, Shaw V, Sjogren B, Sobey C, Spicer MM, Squires KE, Sutton L, Wendimu M, Wilkie T, Xie K, Zhang Q, Zolghadri Y. Alexander SPH, et al. Among authors: druey km. Br J Pharmacol. 2023 Oct;180 Suppl 2:S1-S22. doi: 10.1111/bph.16176. Br J Pharmacol. 2023. PMID: 38123153 Free article. Review.
108 results